- Cyclin-dependent kinase 4
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See all on WikipediaCyclin-dependent kinase 4 - Wikipedia
Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member of the cyclin-dependent kinase family, a group of serine/threonine kinases which regulate the cell cycle. CDK4 regulates the G1/S transition by contributing … See more
The CDK4 gene is located on chromosome 12 in humans. The gene is composed of 4,583 base pairs which together code for the … See more
CDK4 is only active during the G1-S phase, which controlled by cyclin D and CDK inhibitors. CDK activity is negatively regulated by cyclin … See more
Cancer
Cancer, or uncontrolled cell proliferation, is believed to result from disturbances to mechanisms that … See more• Cyclin-Dependent+Kinase+4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• CDK4 human gene location in the UCSC Genome Browser.
• CDK4 human gene details in the UCSC Genome Browser See moreCDK4 is the catalytic subunit of the protein-kinase complex CDK4-cyclin D, which plays a role in G1/S cell cycle progression. During G1 phase, the cell grows and prepares for the DNA replication that occurs in the S phase. There is a G1/S … See more
Wikipedia text under CC-BY-SA license CDK4 Gene - GeneCards | CDK4 Protein | CDK4 Antibody
Mar 30, 2025 · Complete information for CDK4 gene (Protein Coding), Cyclin Dependent Kinase 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
CDK4: a master regulator of the cell cycle and its role in cancer
Although Cdk 4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in …
CDK4 Gene Mutations: Risks, Management and …
Mar 14, 2025 · An inherited CDK4 mutation may affect your options for cancer prevention, detection and treatment. Learn more about your risks and medical options. FORCE is here to guide you.
Genetic Disorder Reference Sheet: CDKN2A/CDK4
Feb 25, 2025 · The cyclin-dependent kinase (CDK) inhibitor 2A (CDKN2A) is a tumor suppressor gene. The CDK4 gene makes a protein for cell division that enables cells to progress from the …
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CDK4 cyclin dependent kinase 4 [Homo sapiens (human)] - Gene
Feb 20, 2025 · The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe …
CDK4 and CDK6 kinases: from basic science to cancer therapy
Cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) and their activating partners, D-type cyclins, link the extracellular environment with the core cell-cycle machinery. Constitutive activation of …
Definition of CDK4 gene - NCI Dictionary of Cancer Terms
A gene that makes a protein involved in the cell cycle (the process a cell goes through each time it divides). Mutations (changes) in the CDK4 gene may cause cells to divide too quickly or in an …
CDK4 - My Cancer Genome
Cyclin-dependent kinase 4 (CDK4) is a gene that encodes a protein that is a member of the serine/threonine kinase family. The protein functions in the progression of the cell cycle at from …
CDK4 Gene Mutations: Cancer Risk
Apr 5, 2025 · People with an inherited mutation in the CDK4 gene have an increased risk for certain types of cancer. Read more about these cancer risks. FORCE is here to guide you.
