To determine whether recombinant cadherin 6 could compete with PAC1 for α IIb β 3 binding sites, PRP was incubated for 15 minutes in the presence of fluorescein isothiocyanate-labeled PAC1 antibody with 10 µg/mL Cdh6_IgG, PECAM_IgG, monomelic IgG, or buffer and 2 µM ADP.

To determine whether recombinant cadherin 6 could compete with PAC1 for αIIbβ 3 binding sites, PRP was incu-bated for 15 minutes in the presence of fluorescein isothiocyanate– labeled PAC1 antibody with 10 μg/mL Cdh6_IgG, PECAM_IgG, monomeric IgG, or buffer and 2 μM ADP.

Apr 26, 2012 · Cdh6_IgG is composed of the extracellular portion of cadherin 6 fused to the Fc domain of human IgG and therefore has a higher molecular weight than the native protein.

Nov 26, 2022 · Results: Two nanobodies (A1 and E8) against human CDH17 with high affinity and high specificity were successfully obtained. These nanobodies could specifically bind to CDH17 protein and CDH17-positive gastric cancer cells. E8 nanobody as a lead was extensively determined for tumor imaging and drug delivery.

B, 10 μg/ mL Cdh6_IgG fusion protein inhibits TRAP-induced aggregation in gel-filtered platelets (P<0.0001). The P-Cdh_IgG control fusion protein had no effect (n=5).

Flow cytometry analysis with Anti-CDH6 (DMC675) on Expi293 cells transfected with human CDH6 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram). Lane : Huh7, whole cell lysate. Secondary : Goat Anti-Rabbit IgG H&L (HRP) at 1/5000 dilution.

Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail.

Thrombosis was evaluated using the FeCl3 and Rose Bengal carotid artery models in C57Bl6 mice treated with anti-cadherin-6 or IgG and wild-type or Cdh6-/mice. Platelet function was compared in wild type and Cdh6-/mice using tail-clip assays and aggregometry.

Jan 4, 2017 · Cadherins (CDH) mediate diverse processes critical in inflammation, including cell adhesion, migration, and differentiation. Herein, we report that the uncharacterized cadherin 26 (CDH26) is...

Rabbit Polyclonal CDH11 antibody (GTX109792). Validated in WB, IHC-P, IHC-Fr. Tested in Human, Mouse.