Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae), also known as CDC73 and parafibromin, is a protein which in humans is encoded by the CDC73 …

Dec 31, 2008 · The diagnosis of a CDC73-related disorder is established in a proband with a heterozygous germline CDC73 pathogenic (or likely pathogenic) variant identified by molecular …

Mar 28, 2025 · CDC73 (Cell Division Cycle 73) is a Protein Coding gene. Diseases associated with CDC73 include Hyperparathyroidism 2 With Jaw Tumors and Parathyroid Carcinoma. …

The CDC73 gene (formerly known as HRPT2) provides instructions for making a protein called parafibromin. This protein is found primarily in the nucleus of cells and is likely involved in …

May 23, 2018 · Here, we found that CDC73, which encodes the cell division cycle 73 and acts as a tumor suppressor, was unexpectedly up-regulated in several cancer types but down …

Oct 12, 2017 · In this study, we performed a nationwide evaluation of germline CDC73 analyses undertaken in pHPT patients in the Netherlands and characterized the clinical manifestations …

Feb 9, 2025 · Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation; CDC73-mutated carcinomas displayed losses …

Dec 21, 2023 · To find alternative ways to target Notch signals, we investigated cell division cycle 73 (Cdc73), which is a Notch cofactor and key component of the RNA polymerase-associated …

CDC73 mRNA was more expressed in male than female patients with lung cancer (Figure 2A, p<0.05). According to TCGA database, CDC73 mRNA expression was positively correlated …

Sep 21, 2023 · Clinical characteristics: The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Primary …