Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell cycle.

Cdc42 has been demonstrated to play a pivotal role in the second phase of insulin secretion. Disorder of Cdc42 will impair normal insulin secretion and contribute to diabetes. The …

Mar 28, 2025 · CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Takenouchi-Kosaki Syndrome and Nocarh Syndrome. Among its related …

Recent studies by conditional gene targeting of cdc42 in mice have revealed its tissue- and cell type-specific role and provide definitive information of the physiological signaling functions of …

Cdc42 is a 21.3 kDa, small GTPase protein encoded by 191 amino acids that belongs to the Rho sub-family of Ras super-family GTPases. There are two isoforms produced by alternative …

A hallmark of endothelial senescence is the persistent up-regulation of pro-inflammatory genes. We identified CDC42 signaling as a mediator of chronic inflammation associated with …

Jun 11, 2020 · The small GTPase Cdc42 is known to regulate neutrophil locomotion by controlling cytoskeleton rearrangement in murine neutrophils. However, the role of Cdc42 in other …

Feb 9, 2025 · The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, …

Cdc42 is particularly known for its unique role in controlling cell polarity and in modulating polarized cell functions, including the proper formation of epithelial tight and adherens …

Jan 4, 2023 · Cdc42 is a highly conserved protein: homologues in various members of the Metazoa show 92–95% similarity with human Cdc42 (Beljan et al. 2020). In humans, Cdc42 is …