CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals.

The Cdc25s, and in particular Cdc25A and Cdc25B, are proto-oncogenes in humans and have been shown to be overexpressed in a number of cancers. [12] The central role of Cdc25s in the cell cycle has garnered them considerable attention from the pharmaceutical industry as potential targets for novel chemotherapeutic (anti- cancer ) agents. [ 5 ]

Mar 28, 2025 · CDC25B (Cell Division Cycle 25B) is a Protein Coding gene. Diseases associated with CDC25B include Microcephaly 11, Primary, Autosomal Recessive and Retinoblastoma. Among its related pathways are Defective Intrinsic Pathway for Apoptosis and Cell Cycle, Mitotic.

Jan 4, 2025 · CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals.

CDC25 phosphatases are key targets of the checkpoint machinery activated in response to DNA damage. They are functionally inactivated or degraded to stop cell-cycle progression. CDC25B activity...

Cell Division Cycle-25 (CDC25) plays an important role in transitions between cell cycle phases by dephosphorylating and activating CDKs. CDC25B and CDC25C play a major role in G2/M progression, whereas CDC25A assists in G1/S transition. Different isomers of CDC25 expressions are upregulated in various clinicopathological situations.

Mar 18, 2021 · The Cdc25B activity is required to induce senescence in human normal fibroblasts. Cdc25B is a protein phosphatase, to test whether the enzymatic activity is important for senescence, a CDC25B-CR mutant carrying both C487S and …

Dec 10, 2024 · CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals.

The three human Cdc25s, Cdc25A, Cdc25B, and Cdc25C, are responsible for the dephosphorylation of pThr14 and pTyr15 and thereby trigger the final activation of the Cdk/cyclin complexes. Cdc25B and Cdc25C are regulators of G2/M through their activity on Cdk2/cyclin A, Cdk1/cyclinA, and Cdk1/cyclin B (Figure 1) .

Cdc25B accumulates from the late S and early G2 phases of the cell cycle and its activity peaks at the G2/M transition [4,5]. Cdc25B is proposed to play a “starter” role in triggering mitosis by dephosphorylation and thereby activating Cdk1/cyclin B at the centrosome level [4,5].