Complement-Induced Cell Death by Rituximab Depends on CD20 …
Jul 3, 2006 · A to C, eight individual CEM-CD20 clones with different CD20 expression levels were used and their sensitivity to rituximab-mediated CDC and ADCC was compared. Results …
The regulation and function of CD20: an “enigma” of B-cell …
Anti-CD20 monoclonal antibodies act through several mechanisms, including complement-dependent cytotoxicity (CDC), complement-dependent cellular cytotoxicity (CDCC), antibody …
Complement-induced cell death by rituximab depends on CD20 ... - PubMed
Jul 1, 2006 · These findings suggest that CDC depends on CD20 expression level and that both CDC and ADCC act complementary. These data give new insights into novel strategies to …
Mechanisms of action of CD20 antibodies - PMC
The success of RTX has led to a general interest in the mechanism of action of CD20 mAbs. CD20 mAbs can induce tumor killing via various mechanisms, such as direct induction of …
Epitope interactions of monoclonal antibodies targeting CD20 and …
Several novel anti-CD20 monoclonal antibodies are currently in development with the aim of improving the treatment of B cell malignancies. Mutagenesis and epitope mapping studies …
Exploring complement-dependent cytotoxicity by rituximab
Jun 20, 2022 · The results demonstrate that CDC outcome in CD20 + B-cell lymphoma is synergistically influenced by choice of RTX isotype, antigen density, tumor structure, and …
Complementing CD20 antibodies’ effector functions | Blood
Mar 20, 2025 · The study from Baskar et al demonstrates that chronic lymphocytic leukemia (CLL) cells from patients during CD20 antibody therapy display significantly reduced levels of CD20 …
Effective clearance of rituximab-resistant tumor cells by breaking …
Oct 25, 2023 · Based on these findings, we developed an asymmetric bispecific antibody (SBU-CD55 × CD20) that simultaneously targets both CD55 and CD20 to effectively eliminate …
Rituximab’s B-Cell Depletion: Insights into ADCC and CDC …
Rituximab is engineered to bind to the CD20 antigen, a molecule expressed exclusively on the surface of B-cells, making it an ideal target in B-cell malignancies and autoimmune diseases. …
The regulation and function of CD20: an “enigma” of
Anti-CD20 monoclonal antibodies act through several mechanisms, including complement-dependent cytotoxicity (CDC), complement-dependent cellular cytotoxicity (CDCC), antibody …