CD99 acts through homophilic interactions and enables homo- or heterotypic cell aggregation. CD99 can mediate diverse cellular processes such as adhesion, transendothelial migration, differentiation, and cell death, thereby affecting immune …

Nov 6, 2013 · From a mechanistic point of view, we propose that CD99 increases MAPK/ERK signaling and recruits activated ERK to cell membrane/cytoplasm, where it may phosphorylate RUNX2, thus leading to increased activity of the master gene of osteoblastogenesis.

Mar 31, 2000 · Treatment of human Jurkat T lymphocytes with anti-CD99 antibody led to activation of three mitogen-activated protein kinase (MAPK) members, ERK, JNK, and p38 MAPK, along with homotypic aggregation.

Mar 31, 2000 · In this study, we showed that CD99 triggered all three members of MAPK subfamily which were regulated differentially. We also showed that CD99 activated MAPKs independently of PI-3K and among them, ERK pathway was essential for CD99-induced homotypic aggregation along with intracytoplasmic Ca 2+.

Apr 4, 2021 · Hypoxia enhanced hP-MSCs proliferation in a manner dependent on HIF-1α-mediated CD99 expression and the MAPK/ERK signaling pathway. CD99 activated pathways that transport ERK1/2 to the nucleus, resulting in increased activity of cell cycle-associated proteins.

CD99 appears to function by blocking a terminally differentiated phenotype that is induced by EWS/FLI, and this process is dependent on changes in MAPK pathway signaling. These data suggest a new therapeutic approach to EWS based on modulating the differentiation of the tumor.

Jul 7, 2017 · CD99 engagement by agonistic ligands elicits the recruitment of SHP2 through the sAC/PKA signaling pathway, resulting in activation of the HRAS/MAPK signaling pathway. MAPK activation leads to the isomerization of FAK and PTPN12 mediated by PIN1, followed by PTPN12 binding to FAK and subsequent dephosphorylation of FAK at Y397, resulting in the ...

Apr 26, 2021 · CD99-specific small interfering RNA or the ERK1/2 signaling inhibitor PD98059 abrogated the hypoxia-induced increase in cell proliferation. Conclusion: Hypoxia promoted hP-MSCs proliferation in a manner dependent on CD99 regulation of the MAPK/ERK signaling pathway in vitro .

In differentiating conditions, CD99-transfected OS cells express osteocyte markers, halt proliferation, and largely die by apoptosis, resembling the fate of mature osteoblasts. CD99 induces ERK activation, increasing its membrane-bound/cytoplasmic form rather than affecting its nuclear localization.

Jan 6, 2018 · CD99 can mediate diverse cellular processes such as adhesion, transendothelial migration, differentiation, and cell death, thereby affecting immune functions, inflammation and cancer metastasis. CD99 can act as an oncogene or …