Sep 3, 2020 · Conventional Sca-1–based analysis can potentially cause misinterpretation of stress-mediated hematopoiesis. CD86 serves as an alternative marker to Sca-1 for assessing …

Sep 3, 2020 · CD86 is a reliable marker to distinguish HSCs and MPPs from committed progenitors in inflammatory conditions. Immunophenotypes typically used to identify HSPCs …

May 24, 2012 · We now report that CD86 loss on stem and progenitor cells closely parallels their loss of lymphopoietic potential. It is a uniquely useful marker for appreciating functional …

Although extremely rare, hematopoietic stem cells (HSCs) are divisible into subsets that differ with respect to differentiation potential and cell surface marker expression. For example, we …

Here, we report that small hairpin RNA (shRNA) mediated LSD1 inhibition causes a remarkable transcriptional activation of myeloid lineage marker genes (CD11b/ITGAM and CD86), …

CD86 molecule is the ligand for both costimulatory (CD28) and coinhibitory (CTLA-4) molecules, and it regulates immune response after allogeneic hematopoietic stem cell transplantation …

In this issue of Blood, Shimazu et al report that some mouse hematopoietic stem cells (HSCs) lack surface expression of CD86, and that these CD86-HSCs are capable of myeloid lineage …

Nov 29, 2018 · We also found that UM171 induces the expression of the inflammatory mediator CD86 on HSC subsets and knockdown of this receptor leads to a loss of long-term HSCs and …

May 24, 2012 · CD86 represents an important tool for subdividing HSCs in several circumstances, identifying those unlikely to generate a full spectrum of hematopoietic cells. A unique subset of …

Sep 3, 2020 · As an alternative strategy, we propose CD86-based analysis to accurately observe infection/inflammation-induced hematopoietic responses. Using CD86-based analysis, we …