CD80 is the ligand for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. [6] [13] Interaction of CD80 with CD28 triggers costimulatory signals and results in enhanced and sustained T-cell activation. In contrast, contrary ...

Mar 28, 2025 · CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Vaccinia and Lymphocytic Choriomeningitis . Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway .

In summary, the CD80 expression was closely correlated with the malignancy of breast cancer, and our findings suggest that CD80 might be a promising target for immunotherapeutic strategies. To the best of our knowledge, this is the first integrative study characterizing the role of the CD80 expression in breast cancer via large-scale analyses.

CD80 is a protein that plays a crucial role in immune responses by interacting with CD4 T cells to fully activate them, increase the expression of co-stimulatory molecules, release pro-inflammatory cytokines, and license dendritic cells to activate CD8 T cells.

Urinary CD80 could serve as predictive marker for the potential responsiveness towards specific immunosuppressive agents. Urinary CD80 could discriminate MCD from other nephrotic syndrome diseases.

CD80 is a cell surface receptor that is activated by binding to CD28 or cytotoxic T lymphocyte antigen 4 (CTLA4). Activated proteins further induce T-cell proliferation and cytokine production. A decade ago, Freeman and colleagues discovered that CD80 and PD-L1 are interrelated (Butte et …

Apr 16, 2021 · The tumor cells with deactivated CD80 (TC-1/dCD80-1) were more immunogenic than parental cells and induced tumors that gained sensitivity to cytotoxic T-lymphocyte antigen 4 (CTLA-4) blockade, as compared with the TC-1 cells.

Current perceptions are based around the concept that CD86 is the initial co-stimulatory ligand based on its more abundant and earlier expression pattern; CD80 has a role following antigen-presenting-cell activation.

CD80 (Cluster of differentiation 80), also known as B7-1, is a type I transmembrane protein belonging to the immunoglobulin superfamily. It has an extracellular immunoglobulin constant-like domain and a variable-like domain crucial for receptor binding.

In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway 4. Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses 5 .