These data suggest that CD8 iTreg and pTreg may play a significant role in the regulation of inflammation during the early phases of aGVHD and support that notion CD8 + Foxp3 + iTreg offer an approach for the GVHD suppression and GVL maintenance.

Nov 6, 2019 · We showed that adoptive transfer of CD8+CD103+ iTregs significantly relieves the chronic graft-versus-host disease with lupus nephritis and CD39 inhibitor mostly abolished the functional activities of these CD8+ iTregs in vitro and in vivo.

CD8 + Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4 + Tregs. They are now at the dawn of their clinical use.

The aim of this study was to evaluate the role of the innate immune system in CD8 (+) iTreg differentiation and function. Naive human CD8 (+) CD25 (-) CD45RA (+) T cells were cultured in Treg-inducing conditions with or without IL-1β, TNFα or monocyte-derived dendritic cells (DCs).

Mar 28, 2016 · Our study uncovers unique differences between alloreactive CD4 + and CD8 + iTregs that can be harnessed to create an optimal iTreg therapy for GVHD prevention with maintained GVL responses.

Dec 23, 2019 · We found that addition of Vit C significantly improved the stability of forkhead box P3 (Foxp3) expression in CD8+ iTregs. Moreover, Vit C-treated CD8+ iTregs exhibited high efficacy in attenuating acute and chronic GVHD.

Nov 1, 2019 · Our study has identified the role of CD8+CD103+ iTregs on attenuating GEC injury and provided a possible application of this new iTregs subset in lupus nephritis and other autoimmune diseases.

Apr 1, 2023 · In the current study, we demonstrated that Rapa enhanced CD8 + iTreg generation following IL-2 and TGF-β stimulation by promoting Foxp3 expression and suppressing T-cell expansion in vitro.

Jul 19, 2014 · Regulatory CD4 + and CD8 + T cells (CD4 + /CD8 + Tregs) are essential for immune homeostasis by virtue of their capacity to suppress the function of other cells of the immune system, thereby suppressing immune responses, inflammation and tissue destruction in the human body 1.

Dec 19, 2019 · Vit C–stabilized CD8 + iTregs have an increased potential to suppress GVHD while preserving the GVL effect. Adoptive transfer of induced regulatory T cells (iTregs) can ameliorate graft-versus-host disease (GVHD) after allogeneic hematopoietic cell …