CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell - antigen interactions.

Sep 10, 2021 · In this review, we discuss the process of deriving tumor antigen-specific TCRs, including the identification of appropriate tumor antigen targets, expansion of antigen-specific T cells, and TCR cloning and validation, including techniques and tools for TCR-T cell vector construction and expression.

Feb 27, 2025 · In this study, we demonstrate that the strength of TCR catch bonds significantly influences CD8’s role in determining TCR specificity. Using single-molecule biophysical and functional...

Generating balanced populations of CD8 + effector and memory T cells is necessary for immediate and durable immunity to infections and cancer. Yet, a definitive understanding of how a diverse CD8 + T cell repertoire differentiates remains unclear.

May 21, 2020 · The TCR recognizes antigens on major histocompatibility complex molecules with the cooperation of CD4 or CD8 coreceptors. After recognition, TCR-induced signaling cascades that propagate...

2 days ago · Advanced exhaustion in CD8 + T cells. Chronic TCR signalling coupled with pro-inflammatory and metabolic cues present in some diseased tissues ultimately results in loss of TCF1 activity (and ...

Mar 17, 2025 · T cells with TCR affinity for MHC-1 become CD8 + T cells, whereas T cells with TCR affinity for MHC-2 become CD4 + T cells. Upon the first encounter of antigen-presenting cells (APCs) in secondary lymphoid organs (e.g., lymph nodes) that detect and bind tumor-specific antigens, naïve CD8 + T cells bind to the MHC-I of the APCs via their TCR ...

It is conceivable that CD8 T cells undergo several cycles of TCR de- and resensitization during the priming process beyond the time points analyzed in this study, and such additional cycles could further shape the TCR affinity spectrum of the developing CD8 T cell response.

Sep 28, 2024 · Here, we review the newly discovered methods to enhance the function of CD8 + T cells against solid tumors, focusing on optimizing T cell receptor (TCR) expression, improving antigen recognition by engineered T cells, enhancing signal transduction of the TCR-CD3 complex, inducing the homing of polyclonal functional T cells to tumors, reversing ...

Feb 23, 2025 · Our findings suggest that engineering the CD8 co-receptor represents a safer and more effective alternative to current TCR engineering strategies, offering enhanced tumor targeting while minimizing the risks of off-target reactivity and autoimmune complications.