The diversity of CD8 + T cell dysfunction in cancer and viral infection
2 days ago · Defective immunity can arise in two conceptually distinct scenarios: first, failed or suboptimal CD8 + T cell priming, resulting in anergy (Fig. 1 and Box 1), and second, …
CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and …
Cytotoxic T cell - Wikipedia
CD8 + T cells are recognized as T C cells once they become activated and are generally classified as having a pre-defined cytotoxic role within the immune system. However, CD8 + T …
Cytotoxic CD8 + T cells in cancer and cancer immunotherapy
Sep 15, 2020 · New generations of cytotoxic T cells with genetically modified or synthetic receptors are being developed and evaluated in clinical trials. Furthermore, combinatory …
A distinct priming phase regulates CD8 T cell immunity by
As CD8 T cells underwent a second phase of stable interactions with DCs, helper CD4 T cells halted briefly before moving on to another DC, whereas regulatory T cells did not stop. This …
New insights on anti-tumor immunity of CD8+ T cells: cancer …
Mar 17, 2025 · Notably, CD8+ T cells are one of the primary tumor-infiltrating immune cells that provide anti-tumor response. Tumor cells and tumor stem cells will resist or evade destruction …
Single-cell transcriptomic analysis reveals CD8 + T cell …
Mar 18, 2025 · CD8 + T cell subsets interact with macrophages through different ligand-receptor networks, including the CCL-CCR signaling pathway and costimulatory molecules. Sorafenib …
The diversity of CD8 + T cell dysfunction in cancer and viral
CD8 + T cells that are repeatedly exposed to antigenic stimulation, such as in the context of progressing neoplasms and chronic viral infections, acquire a dysfunctional or hypofunctional …
Distinct CD8 + T cell dynamics associate with response to …
Mar 13, 2025 · Li et al. analyze CD8+ T cells collected from HNSCC patients treated with neoadjuvant immunotherapies. They show that different combination immunotherapies …
Cytokines and the Inception of CD8 T Cell Responses - PMC
In this article we discuss how inflammatory cytokines and IL-2 bias the initial response towards short-lived effector generation and also highlight the potential counterbalancing role of IL-21.