CD8+ T cells pump the brakes on Alzheimer's disease. CD8 + T cells pump the brakes on Alzheimer's disease Nat Immunol. 2023 Oct;24(10):1597-1598. doi: 10.1038/s41590-023 …

Sep 7, 2023 · A recent study identified a microglia–T cell communication axis that retains CD8+ T cells in brains with amyloid pathology.

Oct 24, 2023 · Together, these findings suggest that a CXCL16-CXCR6 axis recruits CD8 + T cells to the brains of mice with AD to suppress microglial function and reduce disease pathology.

RMcellscanactasamolecular‘brake’toreducemicroglialactivation, limit deposition of amyloid-β and ultimately slow Alzheimer’s disease progression.

We recently identified CD8 + T-cells in the brain parenchyma of APP-PS1 transgenic mice being tightly associated with microglia as well as with neuronal structures. The functional role of CD8 …

Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and …

Jun 3, 2021 · In this study, we further characterized a novel tool, a photoactivatable proton pump called “OptoMito-On,” to increase mitochondrial ATP production in CD8 + T cells with the aim …

Aug 30, 2022 · CD8 + T cells increase drug effluxing and aldehyde dehydrogenase expression in allogeneic reactions, enhancing resistance to cyclophosphamide. Common γ-chain cytokines …

Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8+ T-cell compartment. They are characterized by …

Here we identify brain-resident CD8⁺ T cells that coexpress CXCR6 and PD-1 and are in proximity to plaque-associated microglia in human and mouse AD brains. We also establish that CD8⁺ T …