The CD8α-PILRα interaction maintains CD8 + T cell quiescence
May 26, 2022 · We show here that CD8α is critical for the maintenance of CD8 + T cells in a physiologically quiescent state in peripheral lymphoid organs. Upon inducible deletion of …
The CD8α–PILRα interaction maintains CD8 + T cell quiescence
May 26, 2022 · We show here that CD8α is critical for the maintenance of CD8 + T cells in a physiologically quiescent state in peripheral lymphoid organs. Upon inducible deletion of …
A new way to maintain CD8 - Nature
Jul 12, 2022 · Recently, a paper published in Science by Zheng et al. reported that CD8α was crucial to physiologically maintain the quiescent state of CD8 + T cells in peripheral lymphoid …
Computational design and crystal structure of an enhanced …
Apr 1, 2007 · Human CD8 is a T cell coreceptor, which binds to pHLA I and plays a pivotal role in the activation of cytotoxic T lymphocytes. Soluble recombinant CD8 alphaalpha has been …
A general pHLA-CD80 scaffold fusion protein to promote efficient ...
Sep 19, 2024 · Herein, we describe a monovalent pHLA-CD80 scaffold fusion protein called APC-mimic, which includes the cognate pHLA complex and co-stimulatory marker CD80, resulting …
CD8 T cell function and cross-reactivity explored by stepwise …
Aug 10, 2022 · Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor (TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the …
RCSB PDB - 2HP4: Computational design and crystal structure of …
Jul 17, 2006 · Human CD8 is a T cell coreceptor, which binds to pHLA I and plays a pivotal role in the activation of cytotoxic T lymphocytes. Soluble recombinant CD8 alphaalpha has been …
Computational design and crystal structure of an enhanced affinity ...
Human CD8 is a T cell coreceptor, which binds to pHLA I and plays a pivotal role in the activation of cytotoxic T lymphocytes. Soluble recombinant CD8 aa has been shown to antagonize T cell …
CD8+ CD28− and CD8+ CD57+ T cells and their role in health and …
CD8 + T cells are pivotal for the recognition and clearance of cells infected by intracellular pathogens 1 and are the key players in antitumor immune response. 2 They receive activation …
Expanded Antigen-Specific Elimination Assay to Measure Human CD8
Jul 18, 2024 · Here we describe the expanded antigen-specific elimination assay (EASEA), a flow cytometric method to quantitatively measure the ability of human antigen-specific memory …
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