May 1, 2018 · PD-1 was rapidly up-regulated in vivo upon activation of naive virus-specific CD8 T cells within 24 h after LCMV infection and in less than 4 h after peptide injection, well before any cell division had occurred.

Here we examined the role of the PD-1 pathway in effector and memory CD8 + T cell differentiation during influenza virus infection using mice lacking PD-1 (PD-1 knockout [KO]) or both ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC) (PD-L1/L2 double knockout [DKO]), or experiencing PD-1 pathway blockade.

Aug 31, 2020 · PD-1 expression by CD8 + T cells and T reg cells negatively impacts effector and immunosuppressive functions, respectively. PD-1 blockade induces both recovery of dysfunctional PD-1 + CD8 + T...

Jul 29, 2019 · We show that PD-1 blockade in suboptimally primed CD8 + T cell conditions results in the generation of dysfunctional PD-1 + CD38 hi CD8 + cells 18, leading to resistance to anti-PD-1 antibody...

Blocking PD-1 signaling during the early phase of acute viral infection enhanced CD8 T cell effector function and viral clearance, demonstrating that PD-1 expression on early activated T cells has an inhibitory role in T cell immunity against viral infection.

In peripheral blood, we observed that PD-1 is mainly expressed on effector T cells rather than by naïve T cell populations. Despite an overall higher PD-1 + CD8 + T cell frequency in the TIL of HPV + HNC patients, HPV − patients had larger fractions of PD-1 high CD8 + T cells.

Oct 30, 2020 · Multi-color fluorescence staining and tissue micro-arrays were used to identify the pathological distribution of CD8+PD-1+CD161 +/− T cells and their potential clinical implication. The...

Sep 10, 2018 · In this study, by using several different techniques to evaluate transcriptional, functional, and metabolic phenotypes as well as the T cell receptor repertoire, we investigated whether PD-1–expressing CD8 + T cells from chronically inflamed tissue sites show signs of exhaustion or terminal differentiation or, rather, show increased effector fun...

Nov 4, 2024 · Depletion of PD-1 + CD8 + T cells using CAR-T cells effectively alleviates the disease. GSDMD-mediated pyroptosis is found to be aberrantly activated in the livers of model mice, and treatment with a GSDMD-specific inhibitor significantly inhibits disease progression.

Aug 25, 2023 · PD-1 + TCF-1 + stem-like CD8 T cells act as critical resource cells for maintaining T cell immunity in chronic viral infections and cancer. In addition, they provide the proliferative burst of effector CD8 T cells after programmed death protein 1 (PD-1)–directed immunotherapy.