CD8+ T-Cell Memory: The Why, the When, and the How
May 3, 2021 · The establishment of protective T-cell immunity requires the differentiation of CD8 + T cells from a naive state to one where pathogen-specific memory CD8 + T cells are capable of responding to a secondary infection more rapidly and robustly without the …
Frontiers | Defining Memory CD8 T Cell
Nov 20, 2018 · This review will focus on our current understanding of heterogeneity within the antigen-specific memory CD8 T cell compartment and classifications of memory CD8 T cell subsets with defined and discrete functionalities.
Memory T-Cell Heterogeneity and Terminology - PMC
Here, we review our current knowledge of differentiation and maintenance of memory and exhausted CD8 T cells, including phenotypic classification, developmental paths, transcriptional and epigenetic features, and cell intrinsic and extrinsic factors.
Foxo1 regulates intestinal tissue–resident memory CD8 T
4 days ago · Tissue-resident memory CD8 T (T RM) cells serve as a front-line defense against microbial pathogens in barrier and mucosal tissues. Accurately predicting the roles of tissue-specific transcription factors (TFs) that regulate T RM biology remains a challenge.
Memory CD8+ T Cells: Orchestrators and Key Players of Innate Immunity ...
Herein, we challenge this classical paradigm by highlighting the “innate nature” of memory CD8 + T cells. First, within the thymus or in the periphery, naïve CD8 + T cells may acquire phenotypic and functional characteristics of memory CD8 + T cells independently of …
Deep profiling deconstructs features associated with memory CD8
Dec 20, 2024 · A bifurcated analysis of memory CD8 + T cells unveiled genes that more accurately correlated with residence and enabled identification of a more refined, albeit imperfect, combination of flow-compatible markers to identify Trm cells in various tissues.
A distinct priming phase regulates CD8 T cell immunity by
These data establish a role for CD4 helper cells in determining the quantity of acute antiviral CD8 T cell responses, in addition to their known function for memory cells (9 – 11).
FTO controls CD8+ T cell survival and effector response by
1 day ago · Upon recognizing the antigen, naïve CD8 + T cells undergo rapid activation, expansion, and differentiation into effector cells, which carry out cytotoxic function and memory cells afterwards ...
Brief blockade of type I IFN increases CD8+ T cell memory
Apr 8, 2025 · A study shows that transient blockade of type I interferon signalling during T cell priming enhances the generation of stem cell-like memory CD8+ T cells after viral infection and mRNA vaccination.
QRICH1 mediates an intracellular checkpoint for CD8 - Science
Mar 14, 2025 · True memory and virtual memory CD8 + T cells can be distinguished by the marker CD49d, which is expressed on the surface of antigen-experienced memory cells but not on virtual memory cells (72).