Transcription Factor IRF4 Promotes CD8 - Cell Press
Reducing IRF4 expression restored the functional and metabolic properties of antigen-specific T cells and promoted memory-like T cell development. These findings indicate that IRF4 …
Transcription Factor IRF4 Promotes CD8 - PubMed
Dec 19, 2017 · Reducing IRF4 expression restored the functional and metabolic properties of antigen-specific T cells and promoted memory-like T cell development. These findings indicate …
IRF4 and BATF are critical for CD8 + T-cell function following
Feb 14, 2014 · Here, we show that the interferon regulatory factor 4 (IRF4) and its cooperating binding partner B-cell-activating transcription factor (BATF) are necessary for sustained CD8 + …
Graded levels of IRF4 regulate CD8+ T cell differentiation and ...
We show that IRF4 is transiently upregulated to differing levels in murine CD8 + T cells, based on the strength of TCR signaling. In turn, IRF4 controls the magnitude of the CD8 + T cell …
IRF4 impedes human CD8 T cell function and promotes cell
Using CRISPR-Cas9 and lentiviral overexpression in CD8 T cells from non-cancerous donors, we show that the T cell receptor (TCR)-induced transcription factor interferon regulatory factor 4 …
The transcription factor IRF4 determines the anti-tumor immunity of CD8
Nov 17, 2023 · We examined how IRF4 deletion affects anti-tumor CD8 + T cells by generating Thy1.1 + Irf4 −/− Pmel-1 and Thy1.1 + Thy1.2 + WT Pmel-1 mice, which were used in a Pmel …
Interferon regulatory factor 4 controls effector functions of CD8 ...
Apr 20, 2021 · The transcription factor IRF4 is required for CD8 + T cell activation, proliferation, and differentiation to effector cells and thus is essential for robust CD8 + T cell responses. The …
IRF4 impedes human CD8 T cell function and promotes cell
Jul 23, 2024 · Using CRISPR-Cas9 and lentiviral overexpression in CD8 T cells from non-cancerous donors, we show that the T cell receptor (TCR)-induced transcription factor …
Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8
To specifically explore the function of IRF4 in antitumor CD8 + T cells, we conducted 3 adoptive cell therapy (ACT) models. Firstly, depleting IRF4.GFP + CD8 + TILs derived from ACT …
IRF4 Modulates CD8 - American Association of Immunologists
Aug 14, 2017 · In this article, we show that IL-2 and IL-15 signaling and STAT5 activation regulate IRF4 expression in CD8 + T cells. Gene-expression profile analysis has also revealed that …