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Transcriptional repressor histone deacetylase
CD4/CD8 double-positive thymocytes express the transcriptional repressor histone deacetylase (HDAC)7, a class IIa HDAC that is exported from the cell nucleus after TCR engagement.
Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in …
journals.aai.org/jimmunol/article/186/8/4782/84864/Histone-Deacetylase-7-Reg…
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Histone deacetylase 7: a signalling hub controlling development ...
In CD8 + T cells, Hdac7 was constitutively phosphorylated on serine 178, independent of any TCR activation signal . Cytoplasmic localisation of Hdac7 was essential for functional …
bioRxiv
https://www.biorxiv.org › content
HDAC7 controls anti-viral and anti-tumor immunity by CD8
Sep 19, 2022 · Here, we identify HDAC7 as a critical regulator of peripheral CD8 + T cells since its deletion impairs anti-tumor and anti-viral immune responses in mouse models of LCMV …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Histone Deacetylase 7 Functions as a Key Regulator of Genes …
Histone deacetylase 7 (HDAC7) is highly expressed in CD4+/CD8+ thymocytes and functions as a signal-dependent repressor of gene transcription during T-cell development. In this study, we …
Studies of CD8 HDAC7
PubMed
Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes
CD4/CD8 double-positive thymocytes express the transcriptional repressor histone deacetylase (HDAC)7, a class IIa HDAC that is exported from the cell nucleus after TCR engagement. Through signal-dependent nuclear export, class IIa HDACs such as HDAC7 mediate signal-dependent changes in gene expressi...
Author: Herbert G Kasler
Published: 2011/04/15
Keywords: National In…
National Center for Biotechnology Information
HDAC1 Controls CD8+ T Cell Homeostasis and Antiviral Response
Reversible lysine acetylation plays an important role in the regulation of T cell responses. HDAC1 has been shown to control peripheral T helper cells, however the role of HDAC1 in CD8+ T cell function remains elusive. By using conditional gene targeting approaches, we show that LckCre-mediated dele...
Author: Roland Tschis…
Published: 2014
Publication: PLoS On…
PubMed
Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes
Histone deacetylase 7 (HDAC7) is highly expressed in CD4(+)/CD8(+) thymocytes and functions as a signal-dependent repressor of gene transcription during T-cell development. In this study, we expressed HDAC7 mutant proteins in a T-cell line and use DNA microarrays to identify transcriptional targets ...
Author: Herbert G Kasler
Published: 2007/7
Keywords: National In…
ScienceDirect
Article HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis
We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4+CD8+ double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and negative selection, via the transcription factor MEF2D. HDAC7 is exported from the nucleus during T c...
Published: 2003/05/01
Cited By: 0
Page Count: 12
PubMed
HDAC7 regulates apoptosis in developing thymocytes
Central immune tolerance is established in the thymus for T cells via a complex selection process that involves interactions between CD4+CD8+ double-positive thymocytes and antigen-presenting cells. Cells that express antigen receptors interacting strongly with self peptide MHC complexes are deleted...
Author: Eric Verdin
Published: 2004
Keywords: National In…
PubMed
https://pubmed.ncbi.nlm.nih.gov
Histone deacetylase 7 regulates cell survival and TCR ... - PubMed
Apr 15, 2011 · CD4/CD8 double-positive thymocytes express the transcriptional repressor histone deacetylase (HDAC)7, a class IIa HDAC that is exported from the cell nucleus after TCR …
- Author: Herbert G. Kasler, Bryan D. Young, Denis Mottet, Hyung W. Lim, Amy M. Collins, Eric N. Olson, Eric V...
- Publish Year: 2011
bioRxiv
https://www.biorxiv.org › content
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HDAC7 controls anti-viral and anti-tumor immunity by CD8
Sep 18, 2022 · Taken together, we identify HDAC7 as a central regulator of cellular exhaustion and apoptosis of peripheral CD8+ T cells, controlling CD8+ T cell dependent anti-tumor and …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
HDAC1 Controls CD8 + T Cell Homeostasis and Antiviral Response
Oct 21, 2014 · HDAC7 regulates both positive and negative selection during T cell development – and class II HDACs (HDAC4, 5 and 10) have been implicated in the ThPOK-mediated …
- Author: Roland Tschismarov, Sonja Firner, Cristina Gil-Cruz, Lisa Göschl, Nicole Boucheron, Günter Steiner, ...
- DOI: 10.1371/journal.pone.0110576
- Publish Year: 2014
- Publication: PLoS One. 2014; 9(10): e110576.
People also ask
Is HDAC7 a thymus-specific class II histone deacetylase?
Dequiedt F, Kasler H, Fischle W, Kiermer V, Weinstein M, Herndier BG, et al. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity. 2003;5:687–98.
Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte
nature.com
Is HDAC7 a self-sustaining autoexcitatory loop?
Remarkably, the activity of protein kinase D, the kinase that mediates nuclear export of HDAC7 in response to TCR signaling, is also increased in HDAC7-deficient thymocytes, suggesting that HDAC7 nuclear export governs a self-sustaining autoexcitatory loop.
Histone deacetylase 7 regulates cell survival and TCR
pubmed.ncbi.nlm.nih.gov
What antibodies are used to purify total DN thymocytes (CD4 - CD8 -)?
Total DN thymocytes (CD4 - CD8 -) were purified by negative selection from the thymus with the following antibodies: anti-MHC class II (M5/114/15/2), anti-CD11b (M1/70), anti-CD4 (GK1.5), anti-CD8 (Tib105), and anti-Ter119 (Ly-76).
Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte
nature.com
Does nurr77 promote cell death in cluster 5 GSK3 Ki thymocytes?
Impaired differentiation of cluster 5 GSK3β KI thymocytes was also demonstrated by GSEA (Fig. 6l). The expression of Nurr77 is often used as a marker of TCR signaling, and it has been shown to promote cell death during negative section of DP thymocytes by self-antigens [31, 32, 33].
Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte
nature.com
Does cluster 7 represent DN4 thymocytes recombination?
Based on the UMAP proximity between cluster 7 with cluster 3 and cluster 5, and the fact that a small fraction of cells in cluster 7 expressed a paired Tcrab (Fig. 6h), most likely cluster 7 cells represent DN4 thymocytes progressing to mitosis from cluster 3 after Tcra recombination and enter cluster 5 as fully differentiated DN4 thymocytes.
Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte
nature.com
How is the CDR3 region of the tcrb gene sequenced?
The deep sequencing of the CDR3 region of the Tcrb gene was performed using the ImmunoSEQ platform (Adaptive Biotechnologies, Seattle, WA, USA). OP9-DL1 cells were co-cultured with sorted DN3 thymocytes in the presence of Necrostatin.
Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte
nature.com
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nih.gov
https://pubmed.ncbi.nlm.nih.gov
Histone deacetylase 7 functions as a key regulator of genes
Histone deacetylase 7 (HDAC7) is highly expressed in CD4 (+)/CD8 (+) thymocytes and functions as a signal-dependent repressor of gene transcription during T-cell development. In this study, …
eLife
https://elifesciences.org › articles
Histone Deacetylase 7 mediates tissue-specific autoimmunity via
Apr 17, 2018 · We report that Histone Deacetylase 7 (HDAC7) controls the thymic effector programming of Natural Killer T (NKT) cells, and that interference with this function contributes …
- Author: Herbert G Kasler, Intelly S Lee, Hyung W Lim, Eric Verdin, Eric Verdin
- Publish Year: 2018
American Association of Immunologists
https://journals.aai.org › jimmunol › article
Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in …
Apr 15, 2011 · CD4/CD8 double-positive thymocytes express the transcriptional repressor histone deacetylase (HDAC)7, a class IIa HDAC that is exported from the cell nucleus after TCR …
nih.gov
https://pubmed.ncbi.nlm.nih.gov
HDAC7 regulates apoptosis in developing thymocytes - PubMed
We have recently reported that HDAC7, a class II histone deacetylase, is highly expressed in CD4+CD8+ double positive thymocytes. HDAC7 inhibits Nur77 expression, an orphan …
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Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in …

Histone deacetylase 7: a signalling hub controlling development ...

HDAC7 controls anti-viral and anti-tumor immunity by CD8

Histone Deacetylase 7 Functions as a Key Regulator of Genes …

Histone deacetylase 7 regulates cell survival and TCR ... - PubMed

HDAC7 controls anti-viral and anti-tumor immunity by CD8

HDAC1 Controls CD8 + T Cell Homeostasis and Antiviral Response

Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte

Histone deacetylase 7 regulates cell survival and TCR

Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte

Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte

Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte

Inactivation of GSK3β by Ser389 phosphorylation prevents thymocyte

Histone deacetylase 7 functions as a key regulator of genes

Histone Deacetylase 7 mediates tissue-specific autoimmunity via

Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in …

HDAC7 regulates apoptosis in developing thymocytes - PubMed

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