Granzyme B in circulating CD8+ T cells as a biomarker of
Nov 9, 2022 · Our study support the involvement of GzmB-expressing CD8+ T cells in the inflammatory response in patients with NMOSD and provide a potential biomarker for disease …
Granzyme B + CD8 + T cells with terminal differentiated effector ...
- Blood samples were collected from 2 RRMS patients with relapse stage and 2 SPMS patients at progressive stage, respectively, and all patients did not receive DMT or steroids in the past 6 months (Fig. 1A, B). After removal of red blood cells and low-quality cells, unsupervised method was applied to partition 35,834 single-cell transcriptomes into 1...
Granzyme B in circulating CD8+ T cells as a biomarker …
In addition to secreting pro-inflammatory cytokines that promote CNS inflammation, cytotoxic CD8+ T cells can also induce target cell death by releasing serine protease granzyme B (GzmB).
Cytotoxic CD8 + T cells promote granzyme B-dependent adverse …
Mar 5, 2021 · Depletion of CD8 + T lymphocytes decreases apoptosis within the ischemic myocardium, hampers inflammatory response, limits myocardial injury and improves heart …
- Author: Icia Santos-Zas, Jeremie Lemarié, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim...
- Publish Year: 2021
Granzyme K + CD8 T cells form a core population in …
Jun 15, 2022 · Using T cell receptor repertoire data, we found that CD8 GzmK + GzmB + T cells are clonally expanded in synovial tissues and maintain their granzyme expression and overall cell state in blood, suggesting that they are …
Visualization of granzyme B-expressing CD8 T cells during primary …
Apr 14, 2015 · In this study we used CD8 T cells from OT1 mice and CD4 T cells from OT2 mice expressing a fluorescent chimeric granzyme (GZMB-Tom) protein to monitor the primary …
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Single-cell atlas of healthy human blood unveils age …
Nov 13, 2023 · This resource revealed 12 subpopulations that change with age, including increased type 2 memory CD4+ and CD8+ T cells and decreased NKG2C+GZMB−CD8+ memory population.
Granzyme B Regulates Antiviral CD8 + T Cell Responses
Dec 15, 2011 · Two recent reports have demonstrated that murine CD4 + CD25 + T reg cells upregulate GzmB in response to TCR activation, and can suppress proliferation of CD4 + …
Interferon-Gamma–Producing CD8+ Tissue Resident Memory T …
CD8 + T cells with a T RM cell phenotype can be identified as cells co-expressing transcripts for CD8A, CD8B, ITGAE, and CD69 (Figure 5 F), and there is evidence for these cells expressing …
Comprehensive Profiling of an Aging Immune System …
Dec 2, 2020 · We defined organ-specific and common immune alterations and identified a subpopulation of age-associated granzyme K (GZMK)-expressing CD8 + T (Taa) cells that are distinct from T effector memory (Tem) cells.
