032080 C57BL/6J-Tg (Cd8a*-cre)B8Asin/J <p><strong></strong><em>E8III-Cre</em> transgenic mice have the E8III enhancer and promoter elements from CD8 antigen, alpha chain …

The transgenic construct also contains GFP, which co-expresses with Cre, but the GFP expression is very low via flow cytometry. These mice may be useful for deletion of …

Endogenous CD8a expression is diminished. These mice may be useful for deletion of genes of interest in CD8a expressing cells.

For the Kl model, the “E8l enhancer-Cd8a promoter-Kozak-Cre-rBG pA" cassette will be cloned into intron1 of ROSA26 in reverse orientation. The insertion site of the Cre recombinase gene …

Mar 5, 2024 · Activated CD8 + T cells treated ex vivo with simultaneous inhibition of A2AR and lipid peroxidation acquire a superior capacity to proliferate and persist in vivo, demonstrating a …

Oct 15, 2019 · Although Cre-loxP systems are invaluable gene-targeting tools, there are multiple potential caveats that should be considered, as recently commented by Becher et al. (2018). …

By using a murine model of imiquimod-induced psoriasis-like dermatitis, we further demonstrated that PD-1 deficiency accelerates skin inflammation with activated cytotoxic CD8 T cells into the …

May 13, 2021 · Persistent antigen encounter by CD8 + T cells during either chronic viral infection or tumour growth leads to a progressive loss of inflammatory cytokine production and …

Because antiviral CD8 T cell required CXCR3 to colocalize with helper CD4 T cells in subfollicular clusters, we investigated whether CXCR3 expression by T reg cells was required to restrain …

Nov 8, 2011 · Cd8a and Cd8b1 coreceptor gene (Cd8) expression is tightly controlled during T-cell development by the activity of five Cd8 enhancers (E8 (I)-E8 (V)). Here we demonstrate a …