Jan 29, 2018 · Growing evidence suggests that CD8+CD28- T cells are a unique subpopulation of regulatory T cells (Tregs) that exert broad effects on directly regulating T cells, such as by inhibiting their...

Typically, CD28 is expressed on about 50% of CD8+ T cells and more than 80% of CD4+ T cells in humans. However, some T cells lose CD28 expression during activation, particularly antigen-experienced T cells, which can be re-activated independently of CD28.

There is growing evidence that the CD8 + CD28 − (CD8 + CD57 +) T-cell population plays a significant role in various diseases or conditions, associated with chronic immune activation such as cancer, chronic intracellular infections, chronic alcoholism, some chronic pulmonary diseases, autoimmune diseases, allogeneic transplantation, as well as h...

In this paper, we provide a comprehensive overview of CD8 + CD28 − senescent T cell population, their origin, their function in immunology and pathologic conditions, including TME and their implication for immunotherapy.

5 days ago · Senescent CD8 + T cells lack CD28 expression but may express increased levels of both activating and inhibitory NK cell receptors, including CD57, CD94 and various KIRs, at least in part owing to ...

Mar 14, 2025 · We stimulated WT mouse primary CD8 + and CD4 + T cells for 24 hours with anti-CD3/CD28 and assessed QRICH1 protein levels via protein immunoblot. In CD8 + T cells, relative QRICH1 protein levels were increased up to 14.5-fold in stimulated cells compared with unstimulated cells, indicating that QRICH1 protein expression is up-regulated within ...

Apr 7, 2025 · Recently, CD28-driven upregulation of arsenic resistance protein 2 (ARS2) was found to enhance the effector functions in CD8 T cells by alternate splicing of PKM2, 14 hinting toward immune-enhancing effects of PKM2 in CD8 T cells. Here, we deciphered the primary roles of PKM2 in CD8 T cells.

Mar 18, 2025 · CD8 + T cell subsets interact with macrophages through different ligand-receptor networks, including the CCL-CCR signaling pathway and costimulatory molecules. ... CD8 + T cells interacting with monocytes/macrophages through co-stimulatory pathways, including CTLA4-CD86 and CD28-CD80, suggesting the formation of active immunological synapses.

Jun 3, 2024 · We observed a decrease in effector CD8 + T cells with high SLAMF7 expression post induction treatment (T2) compared to baseline (T1) in treatment arms including Elo-RVd during induction therapy...

Results: It was found that in high-activity SLE patients, the CD8 + CD28 + T-cell subset was reduced, which was inversely correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and that the CD8 + CD28 - /CD8 + CD28 + ratio was elevated, which was positively correlated with SLEDAI and with renal damage and inversely cor...