CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck. Phosphate-buffered solution, pH …

CD8 Antibody, anti-human, APC, REAfinity™ [130-110-679] This anti-CD8 antibody was tested in order to establish a panel to describe and distinguish peripheral blood lymphocytes (from human PBMCs). Clone REA734 recognizes the human CD8 antigen, a cell-surface glycoprotein also known as Leu-2 or CD8a.

The CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules, resulting in increased adhesion between the CD8+ T lymphocytes and target cells. Binding of the CD8 antigen to class I MHC molecules enhances the activation of resting T lymphocytes.

CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation.

Description: The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule. CD8a is an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alpha alpha).

Human peripheral blood lymphocytes were stained with CD3 PE and CD8 (clone SK1) APC/Fire™ 750 (top) or mouse IgG1, κ APC/Fire™ 750 isotype control (bottom). Need larger quantities of this item? CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b.

CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR …

Mouse Monoclonal CD8 alpha antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Tissue preparation containing CD8A protein.

Invitrogen Anti-CD8 Monoclonal (3B5), Catalog # MHCD0805. Tested in Flow Cytometry (Flow) applications. This antibody reacts with Human samples. Supplied as 500 µL purified antibody.

Invitrogen Anti-CD8 Monoclonal (RFT8), Catalog # A15448. Tested in Flow Cytometry (Flow) applications. This antibody reacts with Human samples. Supplied as 100 µg purified antibody (0.1 mg/mL).