Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene.

Mar 28, 2025 · CD79A (CD79a Molecule) is a Protein Coding gene. Diseases associated with CD79A include Agammaglobulinemia 3, Autosomal Recessive and Agammaglobulinemia 3. Among its related pathways are Autodegradation of the E3 …

CD79 is composed of two distinct chains called CD79A and CD79B (also known as Igα and Igβ); these form a heterodimer on the surface of a B cell stabilized by disulfide bonding. [1] CD79a and CD79b are both members of the immunoglobulin superfamily.

Igα (CD79a)/Igβ (CD79b) are essential components of BCR that are indispensable for its functionality, signal initiation, and signal transduction. CD79a/CD79b-mediated BCR signaling is required for the survival of normal as well as malignant B cells via a wide signaling network.

Jan 4, 2025 · Gene target information for CD79A - CD79a molecule (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Nov 15, 2022 · Our study highlights that CD79A and CD79B are required for surface IgM expression in human B cells and illuminates the importance of the IgM expression level for signaling and fitness.

Aug 15, 1995 · In this report, we describe a new anti-CD79a monoclonal antibody, JCB117, which reacts with human B cells in paraffin embedded tissue sections, including decalcified bone marrow trephines.

Five patients in whom the majority (> 80%) of HRS cells expressed CD79a consisted of 4 males and 1 female aged between 52 and 81 years; 4 of them were in a limited clinical stage. We concluded that CD79a-positive CHL may have unique clinicopathological features. Keywords: classic Hodgkin lymphoma, CD79a, prognosis, immunohistochemistry INTRODUCTION

Our study highlights that CD79A and CD79B are required for surface IgM expression in human B cells and illuminates the importance of IgM expression level for signaling and fitness. The development and function of B cells depend on signals from the B-cell receptor (BCR).

Jul 29, 2010 · In a 2-year-old Turkish girl with agammaglobulinemia-3 (AGM3; 613501), Minegishi et al. (1999) identified a homozygous mutation in the CD79A gene (112205.0001). The findings indicated that CD79A plays an important role in B-cell development.