Jun 30, 2013 · T reg cells also contained a higher abundance of CD71 (the transferrin receptor) and, to a lesser extent, CD98 (a subunit of the l -amino acid transporter), key nutrient receptors that depend...

Sep 10, 2021 · CD98 and CD71 expression was significantly increased on the FSC high NK cell population from FV-infected mice (Fig. 2d, e).

While rapamycin can reduce thymocyte proliferation and the expression of CD71 and CD98, it does not inhibit the process of differentiation. Interestingly, numerous extracellular cues can facilitate mTOR activity in a developing thymocyte including the Notch pathway.

The increased expression of distinct nutrient transporters, such as the transferrin receptor CD71, which mediates iron uptake, CD98, which is involved in glutamine transport, and the phosphate transporter also underscores how nutrient availability contribute to …

Jul 20, 2018 · As nutrient availability in blood and tissues can significantly differ, we examined NK cells isolated from paired blood-liver and blood-spleen samples and compared expression of the nutrient transporters Glut1, CD98 and CD71.

Jun 6, 2002 · CD98, an early marker of T-cell activation, is an important regulator of integrin-mediated adhesion events. Previous studies suggest that CD98 is coupled to both cellular activation and transformation and is involved in the pathogenesis of viral infection, inflammatory disease, and cancer.

Jul 20, 2018 · We examined the expression of Glut1, an important transporter for glucose into cells, CD98, a transporter for amino acids, and CD71, a transporter for transferrin, on NK cells derived from peripheral blood and patient-matched liver and spleen tissues.

We show that CD71, a transferrin receptor, and CD98, a heterodimer glycoprotein involved in both integrin signaling and amino-acid transport, are both highly upregulated on proliferating T cells upon in vitro stimulation, and that CD71 expression is maximal on the more recent progeny T cells, while CD98 upregulation remains stable across ...

In this mini-review, we discuss the physiological functions of CD98hc, its role in regulating tumor stemness, metastases, and therapy resistance, and the clinical significance of CD98hc as a...

Our results showed that CIML NK cells express higher levels of CD98 and GLUT1 than control NK cells at day 7 (Fig. 1, right column). On the other hand, no significant differences were found in the expression of CD71 and GLUT3 between control and CIML NK cells (Fig. 1, right column).