Transferrin receptor protein 1 (TfR1), also known as C luster of D ifferentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. [5][6] TfR1 is required for iron import from transferrin into cells by endocytosis. [7][8] TfR1 = transferrin receptor 1 in Human iron metabolism.

May 14, 2021 · CD71 is a robust immunohistochemical marker in gestational pathology, used for identifying nucleated red blood cells that can help in excluding a complete mole, and for identifying chorionic villi to demonstrate gestation even in the case of massive necrotic hemorrhagic modifications

CD71 (transferring receptor-1) is known to be expressed in the earliest erythroid precursors, and has been useful for flow cytometry. However, CD71 is also regarded as a proliferation marker, and its lineage specificity has not been systemically investigated …

CD71 is a highly effective marker for the detection of cells of erythroid lineage in bone marrow biopsy specimens. Accurate analysis of the erythroid lineage is essential in evaluating bone marrow biopsy specimens and can be particularly challenging in the setting of dyserythropoiesis.

Nov 16, 2012 · CD71 (transferring receptor 1) is an integral membrane glycoprotein that plays an important role in cellular uptake of iron. It is well known as a marker for cell proliferation and activation.

Oct 27, 2020 · Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed. Here,...

Sep 1, 2010 · Transferrin receptor (CD71) mediates the uptake of transferrin-iron complexes and is highly expressed on the surface of cells of the erythroid lineage. Although CD71 has been used for flow cytometric analysis, its usefulness in paraffin-embedded bone marrow biopsy specimens has not been examined.

Dec 1, 2021 · CD71 + erythroid cells (CECs) are immature red blood cells, including erythroblasts and reticulocytes (Elahi et al., 2013). CECs are characterized by the expression of transferrin receptor I (CD71) and erythroid lineage markers, glycophorin A (CD235a) in humans and glycophorin A-associated protein (TER119) in mice (Fig. 1).

Mar 17, 2021 · The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf.

Mar 17, 2021 · The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf.