Immunochemistry at the protein level revealed that helper T cells and the macrophage markers CD4 and CD68 could successfully distinguish different CTCL stages in patients, whereas the …

Our findings suggest that expression of hCD46 on NPIs potentially provides a measurable incremental survival advantage in vivo by reducing early thrombo-inflammatory events …

CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. [5] …

CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue …

Jun 10, 2015 · Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement. This type-I …

CD68 + cells are a functionally active subset of macrophages that are associated with increased iNOS and arginase staining and altered gene expression.

In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of …

Hand-in-hand with better understanding of the role of CD46 in endothelial biology as protector of the vascular space against unwanted complement deposition came the realization that the …

CD46, a membrane cofactor expressed on all nucleated human cells, plays an essential role in suppressing autoimmune reactions and protecting host cells from complement-mediated …

Feb 8, 2025 · CD68’s exploration extends beyond its role as a tissue marker, unveiling a spectrum of immunological functions. Its involvement in macrophage functionality influences immune cell …