CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia).

Feb 7, 2025 · CD68 positive cells, primarily macrophages, have garnered attention for their role in cancer prognosis due to their involvement in tumor immune responses and impact on disease outcomes. Understanding these cells is crucial for insights …

Mar 28, 2025 · CD68 (CD68 Molecule) is a Protein Coding gene. Diseases associated with CD68 include Granular Cell Tumor and Histiocytic Sarcoma. Among its related pathways are Innate Immune System and Macrophage markers. An important paralog of this gene is LAMP1.

Nov 21, 2016 · CD68 is a heavily glycosylated glycoprotein that is highly expressed in macrophages and other mononuclear phagocytes. Traditionally, CD68 is exploited as a valuable cytochemical marker to...

CD68 is a valuable marker which can be used to identify macrophages and monocytes, and also has implications in the diagnosis of various disease conditions.

CD68 plays a critical role in promoting phagocytosis; however, the function of CD68 in tumor immunity and prognosis remains unknown. We analyzed CD68 expression among 33 tumor and normal tissues from The Cancer Genome Atlas and Genotype-Tissue Expression datasets.

Feb 24, 2014 · CD68 is a type I transmembrane glycoprotein present in macrophages and monocytes and CD68 antibodies may be used to distinguish between Crohn’s Disease and Chronic Granulomatous Disease. Read the Blog!

CD68 is a specialized type of protein highly expressed in cells of the monocyte-macrophage lineage. It serves as a marker for these cells in various tissues and is involved in the immune system’s response to pathogens and the clearance of cellular debris.

CD68 is a sialomucin and a member of the scavenger receptor supergene family that is expressed by various types of immune cells, including monocytes, macrophages, dendritic cells, and neutrophils, as well as some non-hematopoietic cells like the epithelium of renal tubules.

Feb 8, 2025 · CD68, a transmembrane glycoprotein, is predominantly expressed on macrophages and serves as a reliable marker for these immune cells. Its structure, characterized by a heavily glycosylated extracellular domain, facilitates its role in phagocytosis and antigen presentation.