May 1, 2022 · In this study, we show that RAB7 is required for lysosomal degradation of the EGF·EGFR complex. Upon dissecting the endocytic pathway of RAB7-deficient cells, we find …

Raw264.7 macrophages transfected with two plasmids encoding either EGFP-fused CD63 or RILP and a dominant-negative form of Rab7, Rab7T22N, were allowed to phagocytose latex …

RAB7, LAMP-1 and CD63 are localized onto late endosomes/MVBs and they are downregulated in chemoresistant cells. RAB7 downregulation causes chemoresistance by increasing release …

In this study, we observe that Rab7 is markedly recruited to LDs in live hepatocellular carcinoma cells when placed under nutrient deprivation. Most importantly, Rab7 is highly activated under …

Apr 29, 2020 · In this study, we improved the stability and brightness of superecliptic pHluorin-CD63 by incorporating a single amino acid mutation, M153R, previously identified to stabilize …

Mar 1, 2013 · Rab7 designates the maturation of endosomes and also autophagosomes, directing the trafficking of cargos along microtubules, and finally, participating in the fusion step with …

Here, it has been demonstrated that a lysosomal glycoprotein, CD63, is recruited to the majority of M.tb phagosomes, while RILP shows limited localization. This is consistent with the author's …

Mar 29, 2019 · Mechanistic studies reveal that LE transport effector RILP prefers ubiquitylation-deficient Rab7, while retromer-mediated LE recycling benefits from an intact cycle of Rab7 …

anti-CD63 antibody. Immunoblotting analysis revealed that CD63 is recruited to live M.tb phagosomes as well as to heat-inactivated M. smegmatis phagosomes. These results suggest …

Nov 3, 2020 · We find that active Rab7 interacts with the NPC1 cholesterol transporter and licenses lysosomal cholesterol export. This process is abolished in C18orf8 -, Ccz1 - and …