CD63 expression in tumor-associated microglia/macrophages was examined by double-immunofluorescence with ionized calcium-binding adapter molecule 1 (Iba1). The association between CD63 and TIMP-1 was investigated using previously obtained TIMP-1 data from our astrocytoma cohort.

To validate the surge in DAM in brain sections, we utilized CD63 as one of its most distinctive membrane markers (Figure 2f, Figure 3c) in conjunction with IBA1. CD74 expression further affirmed their DAM status (Figure S6a,b ).

This article reviewed the characteristics and functions performed individually by TIMP1, CD63, and β1-integrin, the roles of the TIMP-1/CD63/β1-integrin complex, both in a physiological context and in cancer, and the regulatory mechanisms involved in its assembly.

Jan 25, 2019 · While there was greater Iba-1 immunoreactivity in NAWM compared to controls, in DSCL, Iba-1 levels were reduced to control levels. A prominent feature of these DSCL was a population of Iba-1 - /CD68 + microglia. There were increases in collagen IV, but no change in …

Mar 9, 2018 · CD63 expression in tumor-associated microglia/macrophages was examined by double-immunofluorescence with ionized calcium-binding adapter molecule 1 (Iba1). The association between CD63 and...

Dec 12, 2017 · Iba1 is a pan-microglial marker whose expression increases with microglial activation, 58, 77 and hence these results indicate that there are increases in the expression of Iba1, but not the ...

Apr 7, 2023 · These SAMs are a subset of CD9+ TREM2+ macrophages that express SPP1, GPNMB, FABP5, and CD63 and are enriched in human and murine hepatic and pulmo-nary fibrosis. RNA velocity suggested that they originate from infil-trating monocytes and represent an intermediate differentiation state.

Jan 20, 2020 · Oil-red-O-positive ‘lipid-laden’ cells, including neurons, astrocytes, ependymal cells and IBA1 + cells, have recently been reported in mice and shown to increase with age 15.

Mar 9, 2018 · CD63 expression in tumor-associated microglia/macrophages was examined by double-immunofluorescence with ionized calcium-binding adapter molecule 1 (Iba1). The association between CD63 and TIMP-1 was investigated using previously obtained TIMP-1 data from our astrocytoma cohort.

Aug 5, 2021 · Here, we assessed microglial morphology in 32 controls, 44 Alzheimer’s disease (AD) cases and 16 AD cases from patients immunised against Aβ42 (iAD) using 2D and 3D approaches. Our 2D assessment...