CD63 is a good marker for flow cytometric quantification of in vitro activated basophils for diagnosis of IgE-mediated allergy. The test is commonly designated as basophil activation test (BAT).

Mar 28, 2025 · CD63 (CD63 Molecule) is a Protein Coding gene. Diseases associated with CD63 include Fundus Albipunctatus and Congenital Stationary Night Blindness . Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System .

This article reviewed the characteristics and functions performed individually by TIMP1, CD63, and β1-integrin, the roles of the TIMP-1/CD63/β1-integrin complex, both in a physiological context and in cancer, and the regulatory mechanisms involved in its assembly.

Oct 13, 2011 · We find that ablating CD63 expression leads to a loss of P-selectin–dependent function: CD63-deficient HUVECs fail to recruit leukocytes, CD63-deficient mice exhibit a significant reduction in both leukocyte rolling and recruitment and we show a failure of leukocyte extravasation in a peritonitis model.

CD63 is a ubiquitously expressed protein that is localized within the endosomal system and at the cell surface (Fig. 1). In most cells the major pool of CD63 resides in late endosomes/MVBs and lysosomes, which is why it is also referred to as a lysosomal membrane protein.

Jun 17, 2024 · Here we report that a key component of small extracellular vesicles, the tetraspanin CD63, sorts cholesterol to ILVs, generating a pool that can be mobilized by the NPC1/2 complex, and exported...

Apr 6, 2025 · CD63 pathway from host multivesicular bodies provides essential lipids to Chlamydia to maintain productive intracellular infection (J Cell Sci 2006;119:350)

Jun 21, 2024 · CD63 contributes to tumor progression through its interactions with TIMP-1, whereby it activates signaling pathways that improve cell proliferation, survival, and migration.

Our finding that pools of CD63 traffic between intracellular compartments raises the question how CD63—a transmembrane molecule—is transported in the cytoplasm. One possibility is that secretory granules in the process of content release acquire CD63 from membrane‐bound transport carriers.

Aug 6, 2021 · In this study, we identify tetraspanin CD63 as a novel functional marker of HSCs in mice. We show that CD63 is unevenly expressed on the cell surface in HSC populations.