CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. [5] It is an LU domain and belongs to the LY6 / uPAR / alpha-neurotoxin protein family .

Feb 16, 2023 · CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 at the...

Mar 1, 2002 · If CD59 can only inhibit the build up of large MACs by preventing subsequent insertion of C9 molecules, formation of either a small-size MAC or the simple C5b-8 complex could render the attacked cells leaky, even in the presence of CD59.

Jun 1, 2023 · CD59 have involved in physiological function, such as immune system regulation and cell protection against the complement system. CD59 bind to and block the activity of C5b-9, hence preventing MAC assembly and protecting cells against complement-mediated lysis.

CD59 is an essential regulatory protein of the complement terminal pathway, the membrane attack complex (MAC). Host cells are protected from complement driven cell lysis by CD59 binding directly to C9 and C5b-8 and inhibiting MAC formation (Davies et al., 1989; Bodian et …

Mar 1, 2002 · Using the whole cell patch clamp method, we were able to measure accumulation of homologous MACs in the membrane of CD59 (-) human B-cells, which formed non-selective ion channels with a total conductance of 360 +/- 24 pS as measured at the beginning of the steady-state phase of the inward currents.

In this review, we describe the structure and biological activities of CD59, the pathogenic role of MAC formation, and discuss application of soluble molecules of CD59 for therapeutic use. CD59 regulates complement activation cascade at the final step, inhibiting formation of membrane attack complex (MAC).

CD59 achieves its inhibitory function by binding to complement proteins C8 and C9 and preventing their assembly into the membrane attack complex (MAC). The MAC is responsible for creating pores in the membranes of target cells, leading to their destruction.

Jun 30, 2023 · CD59 is a GPI-anchored cell surface receptor that serves as a gatekeeper to controlling pore formation. It is the only membrane-bound inhibitor of the complement membrane attack complex (MAC), an immune pore that can damage human cells.

Jan 1, 2018 · CD59 inhibits the formation of membrane attack complex (MAC) pores in the membranes of expressing cells: it is a ‘suicide inhibitor’, locking onto C8 in the forming MAC to block the recruitment of C9 into the complex.