Sep 15, 2006 · CD59 is a membrane glycoprotein that regulates formation of the cytolytic membrane attack complex (MAC or C5b-9) on host cell membranes. It functions by binding to …

Feb 16, 2023 · CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement …

CD59 is a membrane glycoprotein that regulates formation of the cytolytic membrane attack complex (MAC or C5b-9) on host cell membranes. It functions by binding to C8 (α chain) and …

CD59 exerts its effect by binding tightly to the C5b-8 complex and inhibiting the incorporation of multiple C9 molecules into the complex (Morgan, 1999) thereby blocking formation of the large …

When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex. [8] It may also …

Mar 1, 2002 · Activation of the complement system on the cell surface results in the insertion of pore forming membrane attack complexes (MAC, C5b-9). In order to protect themselves from …

Nov 1, 1993 · We have examined the interactions of CD59 with the terminal complement complexes using soluble CD59 purified from human urine (CD59U). CD59U bound to SC5b-8, …

Nov 1, 1993 · Unlike acylated myocardial CD59 (CD59H) neither CD59U nor PIPLC-treated CD59H became incorporated into poly-C9 complexes, suggesting that the interaction of CD59 …

CD59 achieves its inhibitory function by binding to complement proteins C8 and C9 and preventing their assembly into the membrane attack complex (MAC). The MAC is responsible …

CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 …