Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene. [5] [6] The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

Mar 28, 2025 · CD53 (CD53 Molecule) is a Protein Coding gene. Diseases associated with CD53 include Autism Spectrum Disorder and Hematologic Cancer. Among its related pathways are Innate Immune System and 11p11.2 copy number variation syndrome. An important paralog of this gene is TSPAN9.

Tetraspanin CD53 is a member of the tetraspanin superfamily expressed exclusively within the immune compartment. Amongst others, B cells, CD4 + T cells, CD8 + T cells, dendritic cells, macrophages, and natural killer cells have all been found to …

The tetraspanin CD53 is required for normal B cell development. CD53 promotes B cell development by maintaining IL-7R signaling. CD53 functions cell autonomously during B lymphopoiesis.

May 21, 2020 · Tetraspanin CD53 is a member of the tetraspanin superfamily expressed exclusively within the immune compartment. Amongst others, B cells, CD4 + T cells, CD8 + T cells, dendritic cells, macrophages, and natural killer cells have all been found to express high levels of this protein on their surface.

We have examined CD53 expression on DP from several class I- and class II-restricted TCR transgenic (Tg) mice, and have found a strong correlation between CD53 expression and positive selection.

Nov 2, 2024 · Title: CD53, a suppressor of inflammatory cytokine production, is associated with population asthma risk via the functional promoter polymorphism -1560 C>T. SNP rs6679497 in gene CD53 showed significant association with TNFalpha levels (P=0.001); no association of this SNP was observed with osteoarthritis

CD53-negative T cells (Cd53 −/−) exhibit substantial proliferation defects, and Cd53 −/− mice show impaired tumor rejection and reduced IFNγ-producing T cells compared with wild-type mice. Investigation into the mechanism reveals that CD53 is required for …

Mar 9, 2023 · CD53 is upregulated in HSCs in response to various inflammatory and proliferative stressors. CD53 promotes HSC return to quiescence via promotion of the DREAM complex activity and downregulation of cycling-associated genes.

Feb 8, 2025 · Ligation of CD53 triggers a survival response and reduces the number of cells that enter apoptosis. The CD53 antigen interactions might contribute to cell survival in poorly vascularized regions of the tumor mass.