Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene. The CD49b protein is an integrin alpha subunit.

Jul 12, 2022 · In this study, we demonstrate that CD49b subdivides the most primitive HSC compartment into functionally distinct subtypes: CD49b - HSCs are highly enriched for myeloid …

Cell membrane receptors used to differentiate leukocyte subpopulations. Examples: CD49b, CD34, etc. A family of cytokines that work through G protein–coupled receptors to induce …

CD49b is expressed on a fraction of effector T cells in the context of arthritis, influenza or LCMV infection, and in tumors, whereas CD49a expression is largely confined to effector cells …

Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) …

Apr 28, 2013 · By gene expression profiling of human Tr1 cell clones, we identified the surface markers CD49b and lymphocyte activation gene 3 (LAG-3) as being stably and selectively …

In this study, we demonstrate that CD49b subdivides the most primitive HSC compartment into functionally distinct subtypes: CD49b − HSCs are highly enriched for myeloid-biased and the …

Oct 1, 2008 · We show that VLA-2 serves as a marker for activation by CD137L-expressing cell-based vaccines, and we demonstrate that the CD49b + population is far more active than …

We have identified a short-lived effector Treg cell subset that expresses the α 2 integrin, CD49b, and exhibits a unique tissue distribution, being abundant in peripheral blood, vasculature, skin, …

Jul 12, 2022 · Our studies demonstrate that CD49b can distinguish between functionally and epigenetically distinct multipotent HSCs with myeloid and lymphoid bias in the primitive HSC …