CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.

Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on T H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.

CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity.

CD40L, also known as gp39, CD154 and TNFSF5, is a type II membrane glycoprotein with a 22 aa cytoplasmic tail a 24 aa transmembrane domain and a 215 aa extracellular domain in human. It was firstly recognized in 1992 on murine activated T helper (Th) cell …

CD40 ligand (CD40L) is a 261-amino-acid membrane glycoprotein expressed on activated CD4 lymphocytes. Expression occurs shortly after T cell activation. The natural ligand for CD40L is CD40, which is a transmembrane protein present on …

Mar 28, 2025 · CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and …

CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity.

CD40L is a member of the tumor necrosis factor (TNF) family of cell surface interaction molecules. It is a 261-amino-acid type II membrane glycoprotein, and its expression is mainly confined to the CD4 +-T-cell subset. CD40L expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes.

Mar 1, 2021 · The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing.

Here, we report the generation and clinical results of a CD40L binding protein, VIB4920, which lacks an Fc domain, therefore avoiding platelet-related safety issues observed with earlier monoclonal antibody therapeutics that targeted CD40L.