This review will focus primarily on a series of studies which have attempted to map the residues which mediate CD4:MHC class II interaction. These data will be evaluated in light of our current understanding of CD8:MHC class I, and CD4:TCR interactions.

May 3, 2021 · CD4 affinity-enhanced p:MHCII tetramers, therefore, allow direct sampling of antigen-specific CD4 + T cells that cannot be accessed with conventional p:MHCII tetramer technology. These...

By combining MHCII allele purification, allele-independent peptide loading, and multiplexed flow cytometry technologies, we can enable high-throughput personalized CD4 + T cell identification, immunophenotyping, and sorting.

MHC class II molecules play a central role in the control of adaptive immune responses through selection of the CD4(+) T cell repertoire in the thymus and antigen presentation in the periphery.

Dec 13, 2024 · Major histocompatibility complex class II (MHCII) bound to a peptide antigen mediates interactions between CD4 + T cells and antigen-presenting cells. Targeting peptide–MHCII with T cell...

Aug 1, 2023 · CD4 + T cells exhibit a high degree of heterogeneity and plasticity and are regulated upon stimulation with cognate antigen bound to MHC class-II (MHC-II) molecules.

By combining MHCII allele purification, allele-independent peptide loading, and multiplexed flow cytometry technologies, we can enable high-throughput personalized CD4+ T cell identification, immunophenotyping, and sorting.

Jun 28, 2019 · Overall, we demonstrate that CD4 T cells induce a P2ry12+ MHCII+ subset of microglia, which play a key role in T cell-mediated effector functions that abrogate AD-like pathology.

Jul 15, 2013 · Using our newly designed murine system in which subsets of APCs are capable of conditionally expressing MHCII in vivo, we have addressed the hypothesis that individual APCs contribute to CD4 T cell–mediated autoimmunity in unique ways by examining the contribution of B cells to CD4 T cell responses.

Salmonella p:MHCII-specific CD4 + T cells are numerically stable during persistent infection. We next studied the kinetics of 2W:I-A b-specific T cells following intragastric infection of 129 mice to determine whether a stable cell population was produced.