Single cell profiling of circulating autoreactive CD4 T cells from ...
Jan 29, 2025 · Here we perform single-cell transcriptomic and T cell receptor analyses of circulating, self-antigen-specific CD4 T cells from patients with AILD and identify a subset of …
Functional heterogeneity of CD4 + T cells in liver inflammation
In this review, we summarize what has been discovered so far regarding the role of the different CD4 + T cell polarization states in the progression of two prominent and still different liver …
A hepatic network of dendritic cells mediates CD4 T cell help
Feb 10, 2024 · CD4 help increased the numbers of gBT-1 T cells in the liver dLNs but not the liver, spleen or blood between 5- and 9-days post-rAAV, however a significant difference was …
Functional heterogeneity of CD4 + T cells in liver inflammation
In this review, we summarize what has been discovered so far regarding the role of the different CD4 + T cell polarization states in the progression of two prominent and still different liver …
CD4+ T-cell subsets in autoimmune hepatitis: A review - PMC
The genetic susceptibility of human leukocyte antigen-II (HLA-II) alleles in AIH and the liver infiltration of CD4 + T cells in AIH indicate the key role of CD4 + T cells in AIH. 1 In this review, …
CD4 T cells promote liver inflammation/injury by reverse signaling …
To dissect T cell functional mechanism, we found that only CD154 blockade, but not IFN-γ neutralization, inhibited local immune activation and protected livers from IRI. Furthermore, …
CD4 + T Cells in Chronic Hepatitis B and T Cell-Directed …
In this review, we summarize what is known about CD4 + T cells in chronic HBV infection and discuss the importance and opportunities of including CD4 + T cells in T cell-directed …
Functional heterogeneity of CD4 + T cells in liver inflammation …
Aug 31, 2021 · In this review, we summarize what has been discovered so far regarding the role of the different CD4+ T cell polarization states in the progression of two prominent and still …
The human liver microenvironment shapes the homing and function of CD4
High and intermediate CD69 expressions mark human hepatic CD4 + T RM and a novel functionally distinct recirculating population, respectively, both shaped by the liver …
In vivo armed macrophages curb liver metastasis through tumor …
5 days ago · CD4 + T cell clonotypes shared between liver parenchyma and metastasis were enriched in the IFNγ CD4 cluster indicating a Th1 skewed state (Fig. 3A, I), which has been …