Feb 21, 2024 · Activated CD4 + T cells produce IFNβ via the STING pathway, which promotes MHC-I antigen (cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer responses. In...

In this study, utilizing IFN-γ–yellow fluorescent protein (YFP) and IL-10–GFP dual reporter mice, we show that primary malaria infection–induced CD4 + YFP + GFP + T cells have limited memory potential, do not stably express IL-10, and are disproportionately lost from the Ag-experienced CD4 + T cell memory population during the ...

Apr 25, 2022 · Here, we report that IFN-γ + CD4 + T cells display direct ex vivo cytolytic activity and demonstrate that genetic ablation of IFN-γ or its blockade inhibits CD4 + CTL generation in vivo....

May 29, 2023 · With the help of functional intravital imaging, we report that interferon (IFN)-γ production but not perforin-mediated cytotoxicity was the dominant mechanism for tumor elimination by anti-CD19...

Mar 18, 2025 · The functional identity of CD4 T cell subsets is dictated by their cytokine profiles, which influence interactions with surrounding cells and shape immune responses. Th1 cells produce IFN-γ, which amplifies their differentiation and directs macrophage activity.

May 17, 2024 · Here, we investigated IFN-γ production by umbilical cord blood-derived human CD4 + T cells that differentiate in response to signals provided by autologous antigen-presenting cells. Our results indicate that the resulting human MP …

Jul 22, 2015 · CD4+ cells expressing Interferon-γ (IFN-γ), following stimulation with specific mycobacterial antigens, identified with flow cytometry (FCM-CD4+IFN-γ+), is a new method for the diagnosis of Mycobacterium tuberculosis (MTB) infection.

Mar 20, 2025 · Interferon-gamma (IFN-γ) is a cytokine produced mainly by immune cells and can affect cancer cells by modulating the activity of multiple signaling pathways, including the canonical Janus-activated kinase/signal transducer and activator of transcription (JAK/STAT) cascade. ... IFN-γ secretion from CD4 + T-cells was increased in patients who ...

Mar 29, 2025 · Finally, we show that IL-12, CD4 + T-cells, and IFN-γ are essential for suppressing viral replication, establishing latency, and preventing reactivation in neurons. Materials and methods. Mice. Mice were strictly age-matched within experiments and handled in accordance with institutional and national guidelines. Newborn mice of both sexes were ...

Dec 27, 2022 · Responsive tumors have an inflammatory and highly immune infiltrated pre-treatment tumor microenvironment characterized by the enrichment of pathways associated with CD4 + T cells, interferons (IFNs), and tumor necrosis factor alpha (TNF-α).