Mar 7, 2022 · The blockade of CD36 markedly inhibited foam cell formation. Compared with blocking CD36 or TLR4 alone, the co-inhibition of CD36 and TLR4 in macrophages further reduced cytokine secretion and more effectively inhibited VSMC migration and proliferation.

Toll-like receptor (TLR)2, TLR4 and CD36 are central in inflammation and the development of atherosclerosis. Oxidized low-density lipoprotein (oxLDL) plays a critical role in this disease through its involvement in the formation of foam cells and the activation of leukocytes.

Nov 15, 2009 · Although purified P. falciparum components activate TLRs, CD36-mediated internalization of intact PEs is not inflammatory. Further, CD36 mediates internalization of particles, including PEs, independently of TLR signaling, but can functionally cooperate with TLRs to enhance internalization.

Mar 15, 2016 · Additionally, this study indicates that CD36 plays a vital role in the LPS-induced activation of downstream signaling cascades and mediates E. coli phagocytosis via TLR4 in pGMECs, which offers...

CD36 may also complex with TLR4 and urokinase receptor in response to oxLDL, mediating proinflammatory cytokine production through NF-κB activation (Kiyan et al., 2014). Whether CD36 fatty acid transport and metabolic regulatory functions are involved in VSMC function awaits further investigation.

Dec 27, 2009 · Our results identify CD36-TLR4-TLR6 activation as a common molecular mechanism by which atherogenic lipids and amyloid-β stimulate sterile inflammation and suggest a new model of TLR...

Our study suggests a key role for oxLDL and downstream CD36/TLR4/TRIF in regulating DPP4 expression. Increased DPP4 in response to oxidized lipids may represent an integrated mechanism linking post-prandial glucose metabolism to …

Nov 15, 2009 · In this study, we demonstrate that targeted activation and internalization of CD36 do not by themselves stimulate proinflammatory cytokine production. Despite the presence of malaria TLR agonists in PEs, CD36-mediated PE internalization was also found to be noninflammatory.

Apr 1, 2014 · Toll-like receptor (TLR)2, TLR4 and CD36 are central in inflammation and the development of atherosclerosis. Oxidized low-density lipoprotein (oxLDL) plays a critical role in this disease through its involvement in the formation of foam cells and the activation of leukocytes.

We used specific activators of TLR2/1, TLR2/6, and TLR4 to investigate the role of CD36 in TLR-induced inflammatory signaling in the brain. We found that CD36 is required for the neuroinflammation induced by TLR2/1 activation, but not by TLR2/6 activation, as in the case of systemic inflammation.