Under the given answers CD34 is the distinguishing marker for soft tissue neoplasms and in the majority of GIST positive. Other markers supporting the diagnosis of GIST are DOG1 and c-KIT (CD117). Answers B and E are incorrect because desmin and SMA are usually negative in GIST but positive in leiomyoma.

Dec 31, 2008 · In normal skin, CD34 reactivity is found in blood endothelial cells, in interstitial and perivascular spindle-shaped and dendritic cells of the reticular dermis, in elongated cells around the midportion of the hair follicles and in spindle cells around the secretory coils of the eccrine sweat glands (Fig. 1). 8,9 Its expression in lymphatic ...

The CD34 expression plays a key role in the differential diagnosis of some tumors, such as dermatofibrosarcoma protuberans, epithelioid sarcoma or pleomorphic hyalinizing angiectatic tumor of soft parts, with important therapeutic consequences.

Jan 8, 2023 · CD34 + cells exhibit high heterogeneity in wound skins and improve wound healing. Herein, we investigated the phenotypic and functional heterogeneity of CD34 + cells in normal, anagen, and diabetic wounds.

CD34+ stromal cells/telocytes (CD34+SCs/TCs) are an important interstitial, perivascular, peri/endoneurial and periadnexal cellular component in the dermis and hypodermis (subcutaneous adipose tissue) of the skin.

CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. [5][6][7] CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens.

Oct 22, 2020 · Superficial CD34+ fibroblastic tumor is a distinctive low grade neoplasm of the skin and subcutis, characterized by a fascicular proliferation of spindled cells with abundant, eosinophilic, granular to glassy cytoplasm, marked nuclear pleomorphism and low mitotic count (Mod Pathol 2014;27:294)

These studies show that CD34 is critical for epithelial carcinogenesis in mouse skin, with effects in stem cell activation and migration of initiated cells out of the hair follicle.

Nov 17, 2021 · CD34 immunofluorescence revealed a severe impairment in the dermal network of TCs/CD34 + stromal cells in bleomycin-treated mice. CD31/CD34 double immunofluorescence confirmed that CD31 − /CD34 + TC counts were greatly reduced in the skin of bleomycin-treated mice compared with control mice.

Superficial CD34 positive fibroblastic tumor is a rare low-grade neoplasm of the skin and subcutis with indolent behavior. This entity has been included in the current World Health Organisation (WHO) classification of soft tissue tumors.