In this review, we highlight the phenotype and function of HEVs in homeostatic, inflamed and tumor-draining lymph nodes, and those of HEV-like blood vessels in chronic inflammatory diseases. Furthermore, we discuss the role and regulation of TA-HEVs in human cancer and mouse tumor models.

High endothelial venules (HEV) are specialized post-capillary venules characterized by plump endothelial cells as opposed to the usual flatter endothelial cells found in regular venules. [1] HEVs enable lymphocytes circulating in the blood to directly enter a lymph node (by crossing through the HEV).

For high endothelial venules (HEV) CD34 to serve as a ligand for L-selectin, the O-linked glycans of HEV CD34 are modified in an exquisitely specific manner with a variety of sialyl- and sulfo-transferases.

Important non-PNAd ligands on HEV that regulate L-selectin-dependent recruitment into peripheral LN include 6-sulpho sialyl Lewis X modified N-linked glycans such as CD34, as well as a minor role for core 2-branched O-linked glycans (51, 52).

Mar 12, 2019 · Maintenance of Chst4, B3gnt3, and MECA-79 expression in iHECs and/or slow turnover of membrane-associated MECA-79 + HEV sialomucins (such as CD34) synthesized before downregulation of Fut7 and Gcnt1 could also play important roles.

Aug 23, 2023 · The single-pass transmembrane sialomucin protein CD34 is a surface marker with regulated EC expression ranging from high to low. CD34 is expressed on early hematopoietic and vascular-associated tissue 8.

It is assumed that the precipitation of the CD34 molecule by the MECA79 antibody lies in the recognition of the HEV-specific carbohydrate ligand of the molecule and that the structure of the ligand is identical on GlyCAM-1 and HEV-CD34.

May 6, 2021 · In this review, we highlight the phenotype and function of HEVs in homeostatic, inflamed and tumor-draining lymph nodes, and those of HEV-like blood vessels in chronic inflammatory diseases. Furthermore, we discuss the role and regulation of TA-HEVs in human cancer and mouse tumor models.

Jul 14, 2023 · CD34 can be expressed on High Endothelial Venules (HEV) of lymphoid organs. The sialyl-Lewis-X (SLeX) glycoform of CD34 participates in the lymphocyte-endothelial cell interaction. However, if SLex is absent, these interactions are inhibited.

Mar 13, 2023 · High endothelial venules (HEVs) are organ-specific and specialized postcapillary venules uniquely poised to facilitate the transmigration of lymphocytes to lymph nodes (LNs) and other secondary lymphoid organs (SLOs).