The expanding role of the BCL6 oncoprotein as a cancer …
CD34+ CML leukemic stem cells (LSCs) upregulate BCL6 in response to TKI in a FOXO-dependent manner. It has been appreciated that CML LSCs are less responsive to TKI than …
BCL6 maintains survival and self-renewal of primary human …
Feb 11, 2021 · Given the link between BCL6 and stem cell transcriptional profiles, we next quantified BCL6 protein levels in immunophenotypically defined LSCs (CD45 dim, CD34 + …
BCL6-mediated repression of p53 is critical for leukemia stem cell ...
Oct 10, 2011 · BCL6 represses Arf and p53 in CML cells and is required for colony formation and initiation of leukemia. Importantly, peptide inhibition of BCL6 in human CML cells compromises …
High-grade B-cell lymphomas with TdT expression: a diagnostic …
Sep 4, 2018 · The neoplastic cells were positive for CD10, CD19, CD20, PAX-5, BCL6 (partial), MUM-1/IRF4, TdT and monotypic surface immunoglobulin light chain expression, but were …
TdT Positive Lymphoma with MYC, BCL2 and BCL6 …
TdT and CD34 antigens are the hallmarks of immature lymphoid neoplasms in the earliest stage blasts (pro-B ALL cells). CD34 and TdT expressions are usually noted parallel to one another. …
Interferon γ is a STAT1-dependent direct inducer of BCL6 ... - Nature
Apr 3, 2017 · IFNγ is a strong and rapid inducer of BCL6 expression in IM treated, but not in untreated primary human CD34+ CML stem cells. Relative BCL6 and IRF1 mRNA levels …
BCL6 Is Required for the Maintenance of Leukemia-Initiating Cells …
Nov 19, 2010 · Studying CD34+ CD38- CML cells from leukapheresis samples of two patients and CML cell lines, we found that overnight incubation with Imatinib resulted in a >12-fold increase …
Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell …
In a genetic experiment, we transduced Bcl6 fl/fl-mCherry pre-B cells with TCF3-PBX1 or an empty vector (EV) control. Cre-mediated deletion (Figure 5B) activated the Bcl6-mCherry …
Interferon γ is a STAT1-dependent direct inducer of BCL6 ... - PubMed
Aug 10, 2017 · B-cell CLL/lymphoma 6 (BCL6) exerts oncogenic effects in several human hematopoietic malignancies including chronic myeloid leukemia (CML), where BCL6 …
Acute myeloid leukemia with BCL6 and KMT2A dual rearrangements
Feb 6, 2025 · Fluorescence in situ hybridization confirmed BCL6 rearrangement in 86.5% of cells (panel C). The blasts were positive for CD34 and BCL6 by immunohistochemistry (panels D-E; …