CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. [5] [6] [7] CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens.

CD34 - 110kDa glycosylated transmembrane protein; it is a marker of vascular endothelial cells and a sensitive but not specific marker for neoangiogenesis

CD34 is primarily known as a biomarker for hematopoietic stem cells (HSCs) and hematopoietic stem precursor cells, but it has also been identified as a marker for several non-hematopoietic cells.

Mar 28, 2025 · CD34 (CD34 Molecule) is a Protein Coding gene. Diseases associated with CD34 include Dermatofibrosarcoma Protuberans and Angiosarcoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical ...

CD34 is a marker of human HSC, and all colony-forming activity of human bone marrow (BM) cells is found in the CD34+ fraction. Clinical transplantation studies that used enriched CD34+ BM cells indicated the presence of HSC with long-term BM reconstitutional ability within this fraction.

Dec 26, 2017 · For almost 30 years, the cell-surface sialomucin CD34 has been used as a marker to identify and enrich HSPCs in preparation for BM transplantation. 1 However, studies have revealed that the CD34 neg fraction of normal human BM is capable of differentiating into CD34 pos subsets that possess a more activated phenotype. 4-6,15 However, the CD34 ...

Aug 10, 2023 · It was first reported that the CD34 + CD45RA – population (from BM, CB, and mobilized-PB sources) comprised early precursors (in a colony forming unit assay, these cells differentiated into compact myeloid and erythroid colonies), whereas the CD34 + CD45RA + population contained B lymphoid as well as more committed myeloid progenitor cells ...

CD34 is a transmembrane glycoprotein that is expressed on early lymphohematopoietic stem cells, progenitor cells, endothelial cells, embryonic fibroblasts, and some cells in fetal and adult nervous tissue. It is also expressed on pluripotent and committed stem cells in …

Jul 14, 2023 · This review recaptures CD34 structure, evolutionary conservation, proposed functions, and role in lung inflammation, to describe current research findings and to provide guidance for future studies on CD34.