Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. [5] [6] [7] [8] PECAM-1 plays a key role …

CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1), is a single chain 130 kDa glycoprotein consisting of 6 Ig-like extracellular domains, a short transmembrane segment and a cytoplasmic tail containing two ITIMs (ImmunoTyrosine Inhibitory Motif).

Mar 30, 2025 · PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with PECAM1 include Angiosarcoma and Hemangioma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is FCRL5.

CD31 signals confer immune privilege to the vascular endothelium. Proc Natl Acad Sci U S A. 2015;112:E5815–5824. doi: 10.1073/pnas.1509627112. This study builds importantly on the results of reference 65 to demonstrate that PECAM-1 ITIM signaling confers cytoprotection to the vascular endothelium exposed to pro-apoptotic stimuli.

CD31, or PECAM-1 (platelet endothelial adhesion molecule), is a cell-cell adhesion and signaling protein with established roles in immune cell transmigration and angiogenesis.

Feb 29, 2012 · CD31 is a 130 kDa platelet–endothelial cell (EC) adhesion molecule that was initially identified from ECs and platelets 1 and later from blood leucocytes. 2 Mature CD31 contains a short [22-amino acid (aa)] NH 2 -terminal peptide followed by six C2-type immunoglobulin (Ig) domains, each flanked by two conserved cysteine residues outside the cell...

CD31, also named platelet endothelial cell adhesion molecule (PECAM), is a surface membrane protein of both endothelial and immune cells and plays important roles in the interaction between the vascular and immune systems.

Sep 13, 2007 · Dangerfield J, Larbi KY, Huang MT, Dewar A, Nourshargh S. PECAM-1 (CD31) homophilic interaction up-regulates α6β1 on transmigrated neutrophils in vivo and plays a functional role in the ability of α6 integrins to mediate leukocyte migration through the perivascular basement membrane.

PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells. CD31 expression reverts the undifferentiated morphology and aggressive behavior of MDA-MB-231 cells, indicating its active role in the morphogenesis of breast ductal in situ carcinomas

Jun 1, 2013 · CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a transmembrane homophilic receptor that is expressed by endothelial cells (ECs), platelets, granulocytes, macrophages, dendritic cells (DCs), T- and B-cells and natural killer (NK) cells.