T Cell Activation Bioassay (NFAT) Protocol - Promega Corporation
The TCR/CD3 Effector Cells (NFAT) are provided in Cell Propagation Model (CPM) format, which includes cryopreserved cells that can be thawed, propagated and banked for long-term use. …
Jurkat-Lucia™ NFAT Cells | NFAT Reporter T lymphocytes
Jurkat-Lucia™ NFAT Cells were specifically designed to assess activation of the NFAT (nuclear factor of activated T cells) transcription factor ipon stimulation with small molecules mimicking …
The TCR/CD3 Efector Cells express endogenous TCR, CD3 and CD28 receptors. When the TCR/CD3 Efector Cells (NFAT) are engaged with an appropriate TCR/CD3 ligand or anti …
T Cell Activation Bioassays - Promega Corporation
Engagement of TCR/CD3 on the cell surface leads to intracellular signaling events and the activation of nuclear transcription factors such as Nuclear Factor of Activated T cells (NFAT). …
NFAT Binding and Regulation of T Cell Activation by the …
We found that Homer2 and Homer3, members of the Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell activation. This is achieved through binding of …
NFAT proteins: key regulators of T-cell development and function
Jun 1, 2005 · Experimental evidence indicates that, during T-cell development, calcium–calcineurin–NFAT signalling is a key regulator of positive selection. NFAT2 and …
Coupled feedback regulation of nuclear factor of activated T-cells ...
Jul 23, 2019 · Model simulation and analysis show that amplified activation of the transcriptional factor NFAT in response to repeated TCR stimulations, a phenomenon central to AICD, is …
T Cell Activation Bioassay (NFAT) Protocol - Promega
The TCR/CD3 Effector Cells express endogenous TCR, CD3 and CD28 receptors. When the TCR/CD3 Effector Cells (NFAT) are engaged with an appropriate TCR/CD3 ligand or anti …
TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and …
The results demonstrated that TIM-3 completely suppressed all NFAT activity to near unstimulated control levels in both PMA/Ionomycin- and anti-CD3/CD28 bead-stimulated …
The TCR/CD3 Effector Cells express endogenous TCR, CD3 and CD28 receptors. When the TCR/CD3 Effector Cells (NFAT) are engaged with an appropriate TCR/CD3 ligand or anti …
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