Apr 24, 2020 · We performed a systematic analysis to explore the different mechanisms of CD28 co-stimulation on the ERK response time. Comparing these model simulations with …

Wan et al. reveal that ICOS and CD28 differentially regulate the ERK kinase pathway and ERK is Tfh-repressive. Repressed by ERK, the transcriptional factor Zfp831 promotes T follicular …

CD28 influences ERK activation by enhancing the phosphorylation kinetics of CD3ζ. Removing ITAMs from CD3ζ speeds up ERK response and reduces negative feedback. Chimeric antigen …

CD28 increases ERK signaling by blocking Rap1 action. CD28 inhibits Rap1 activation because it selectively stimulates an extrinsic Rap1 GTPase activity. The ability of CD28 to stimulate Rap1 …

CAR due to the presence of CD28 speeds up the ERK response time across the full range of stimulation levels simulated. In comparison, the effects of adaptor proteins binding to CD28 …

Mar 1, 2020 · We performed a systematic analysis to explore the different mechanisms of CD28 co-stimulation on the ERK response time. Comparing these model simulations to experimental …

Jul 5, 2006 · CD28 is an activating receptor that stimulates the cytotoxicity of YTS cells (as well as human pNK cells), whereas LFA-1 fails to do so. Crosslinking of CD28 and LFA-1 results in …

Using the T cell leukemic cell line Jurkat as a model for T cell activation, we demonstrate that cross-linking CD28 using monoclonal antibodies causes tyrosine phosphorylation and …

Apr 24, 2020 · Experimental measurements of ERK response in CAR-engineered T cells validate the model-generated hypothesis that CD28 activates ERK primarily through modifications of …

Oct 20, 2009 · We report that signaling through the ERK and JNK pathways is decreased in CD4+CD28– relative to CD4+CD28+ cells from the same individuals and that ERK and JNK …