A comparison of chimeric antigen receptors containing CD28 ... - Nature
Jul 6, 2021 · Herein, we provide an overview of T cell costimulation by CD28 and 4-1BB and, using the available preclinical and clinical data, compare the efficacy and toxicity profiles …
CD28 CAR T Cells for the Treatment of T Cell Malignancies
Nov 2, 2023 · We analyzed specific CAR activity against CD28 expressing T-ALL cell lines after retroviral transduction into primary human T cells. Additional CD28 knockout (KO) by …
CD28 Costimulatory Domain-Targeted Mutations Enhance …
Nov 20, 2020 · In vivo, we found that mice given CAR T cells with only a PYAP CD28 endodomain had a significant survival advantage, with 100% of mice alive after 62 days …
CD28 Costimulatory Domain–Targeted Mutations Enhance …
Our results demonstrated that CAR T cells with a mutant CD28 endodomain have better survival and function. This work allows for the development of enhanced CAR T-cell therapies by …
CD28 hinge used in chimeric antigen receptor (CAR) T-cells
Aug 31, 2024 · Here, we apply biophysical methods to characterize the structure and dynamic properties of the CD28 CAR hinge (CD28H) used in an FDA-approved CD19 CAR for the …
Advances in CAR optimization strategies based on CD28 - PMC
This review summarizes the limitations associated with the application of CD28-based CAR-T cells, evaluates the efficacy of current optimization strategies for CD28-based CAR design, …
Chimeric antigen receptor signaling: Functional consequences …
May 20, 2020 · CD28-based CARs seem to elicit stronger T cell activation as compared with 4-1BB–expressing CARs, tending toward an effector-like phenotype, with high interleukin-2 (IL …
Synergistic T cell signaling by 41BB and CD28 is optimally …
Dec 21, 2021 · Second generation (2G) chimeric antigen receptors (CARs) contain a CD28 or 41BB co-stimulatory endodomain and elicit remarkable efficacy in hematological malignancies. …
The CD28-Transmembrane Domain Mediates Chimeric Antigen …
The findings that anti-CD28 can activate CAR T cells through the CAR-CD28 heterodimers raised the concern that the natural ligand of CD28 may also induce off-target activation of CAR T cells.
CAR NK cells with CD28 costimulation improved cell persistence …
Jun 20, 2024 · Adding CD28 costimulation to cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cells targeting CD70+ cancers significantly enhanced antitumor efficacy and …