Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. [5]

Dec 24, 2024 · CD274, also commonly referred to as PDL1, is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. PD1 expression has been observed in a variety of cancers including melanoma and non-small cell lung cancer.

Aberrantly expressed CD274 allows tumor cells to evade host immune system and is considered to be a mechanism of adaptive immune resistance. Inhibition of the CD274/PDCD1 immune checkpoint offers a promising new therapeutic strategy.

Feb 9, 2025 · Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response.

Jan 14, 2022 · Programmed death ligand 1 (PDL1; also known as CD274 and B7-H1) is an immune checkpoint molecule that was discovered to be expressed by heart, placenta, lung and skeletal muscle tissues and...

This gene has 5 transcripts (splice variants), 1 paralogue and is associated with 45 phenotypes. Sorry, the page request "/Homo_sapiens/Component/Gene/Summary/gene_summary?db=core;g=ENSG00000120217;r=9:5450503-5470566;time=1742826726506.506" failed to load.

CD274 is a prognostic marker in Kidney renal clear cell carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

Nov 17, 2016 · CD274 (programmed death ligand 1, also known as B7H1) is expressed in both solid tumors and hematologic malignancies and is of critical importance for the escape of tumor cells from immune surveillance by inhibiting T cell function via its receptor, programmed death 1 …

These data revealed a novel mechanism that miRNAs targeting the CDS of immune checkpoint genes are functional, have prognostic relevance, and also the potential for the development of novel miRNA‐based therapies. Keywords: biomarker, melanoma, microRNAs, PD‐L1/CD274, therapeutic target.

Nov 5, 2024 · Clinical resource with information about CD274, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.