CD244 is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule family of receptors (SLAMF) which are expressed in different types of hematopoietic cells. [6] CD244 plays a role in the regulation of the immune system. [7] A ligand of CD244 is CD48 (SLAMF2).

Mar 30, 2025 · CD244 (CD244 Molecule) is a Protein Coding gene. Diseases associated with CD244 include Rheumatoid Arthritis and Tuberculosis . Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Lymphoid Cells Differentiation .

Mar 24, 2021 · CD244 is a regulatory receptor present in various immune cells, and can therefore be regarded as an immune checkpoint that regulates the immune response and kills tumor cells. CD244 can also be used for construction of a chimeric antigen receptor (CAR) on NK cells.

Mar 24, 2021 · CD244 is a cell surface protein expressed by NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. CD244 binds to the ligand CD48 on adjacent cells and transmits stimulatory or …

Apr 15, 2024 · In this study, we explored the CD244 expression profile across 33 tumor types based on The Cancer Genome Atlas project, the Gene Expression Omnibus database, and other bioinformatics tools. We found down-regulated expression levels in seven tumor types and up-regulated expression levels in two tumor types.

Here, we assess the therapeutic potential of CD244 (2B4/signaling lymphocyte activation molecule family 4), an immunoregulatory receptor found on a variety of immune cells, including exhausted CD8 + T cells, dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs).

Nov 28, 2018 · CD244 is a Signaling Lymphocyte Activation Molecule (SLAM) family immunoregulatory receptor found on many immune cell types—including NK cells, a subset of T cells, DCs, and MDSCs—that represents a potential therapeutic target. Here, we discuss the role of CD244 in tumor-mediated immune cell regulation.

Nov 28, 2018 · CD244 is a Signaling Lymphocyte Activation Molecule (SLAM) family immunoregulatory receptor found on many immune cell types-including NK cells, a subset of T cells, DCs, and MDSCs-that represents a potential therapeutic target.

CD48 is a ligand for the immunoreceptors CD2 and CD244 (2B4). Its activation involves signaling molecules such as Src kinases and caveolin (Shin and Abraham, 2001).

Recently, CD244 has been highlighted as a surface antigen to distinguish PMN-MDSCs from normal neutrophils (11,16–18). Here, CD244 is an immunoregulatory transmembrane receptor molecule that belongs to the signaling lymphocyte activation molecule (SLAM) family .