- CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin.en.wikipedia.org/wiki/CD23
CD23 provides a noninflammatory pathway for IgE-allergen …
CD23/FcεRII, the low-affinity receptor for IgE, is constitutively expressed on B cells and has been shown to regulate immune responses. Simultaneous binding of IgE to FcεRI and CD23 is …
- Author: Paul Engeroff, Flurin Caviezel, David Mueller, Franziska Thoms, Martin F. Bachmann, Monique Vogel
- Publish Year: 2020
The Role of CD23 in IgE Dependent Signaling: Implications from ...
CD23 has been proposed to participate in both a positive and a negative feedback mechanism in the regulation of IgE synthesis by B cells (3, 4). Human B cells undergo isotype class …
CD23 - Wikipedia
CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.
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The role of CD23 in the regulation of allergic responses - PMC
Here, we focus on CD23 and discuss several mechanisms related to IgE binding, as well as the impact of the IgE/antigen‐binding on different immune cells expressing CD23. One recent …
The Low Affinity IgE Receptor (CD23) Is Cleaved by the ...
The low affinity IgE receptor, Fc∊RII (CD23), is both a positive and negative regulator of IgE synthesis. The proteinase activity that converts the membrane-bound form of CD23 into a …
IgE binds asymmetrically to its B cell receptor CD23
Mar 31, 2017 · Two lectin-like “head” domains of CD23 bind to IgE-Fc with affinities that differ by more than an order of magnitude, but the crystal structure reveals only one head bound to one …
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CD23 surface density on B cells is associated with IgE levels and ...
Uptake of allergen-IgE complexes into B cells and activation of allergen-specific T cells depended on IgE binding to CD23 and were associated with CD23 surface density. Addition of …
CD23+IgG1+ memory B cells are poised to switch to …
Feb 7, 2024 · Our findings indicate that CD23 + IgG1 + memory B cells transcribing germline IGHE are a unique memory population containing precursors of high-affinity pathogenic IgE-producing cells that are likely to be …
The role of CD23 in the regulation of allergic responses
Dec 30, 2020 · Here, we focus on CD23 and discuss several mechanisms related to IgE binding, as well as the impact of the IgE/antigen-binding on different immune cells expressing CD23. One recent paper has shown that free IgE …
The structure of human CD23 and its interactions with IgE and CD21
The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcɛRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates …
